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JANUS G3 BioTx Pro Workstation

The JANUS G3 BioTx Pro Pus workstation using Atoll RoboColumn products

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Automated liquid handling platform for small-scale protein purification applications.

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For research use only. Not for use in diagnostic procedures.

ALH1234

JANUS G3 BioTX Pro Workstation

ALH1235

JANUS G3 BioTX Pro Plus Workstation

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Overview
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Overview

The JANUS^® G3 BioTx^™ Pro workstations enable consistent small scale protein purification and sample prep for analytical protein characterization required to support quality by design experimentation in both upstream and downstream processes. The JANUS BioTx Pro workstations are intuitive, flexible, automated instruments capable of performing parallel small-scale analytical protein purification. A graphical user interface accommodates a variety of screening experiments designed to determine the optimal conditions for purification of biotherapeutic proteins using small-scale, commercially available ion exchange and affinity chromatography solutions. With just one instrument, you can achieve rapid analysis of a range of sample volumes and concentrations to support Quality by Design experimentation in both upstream and downstream processes:

Expression optimization
Cell line selection
Purification process development
Bioanalytical sample prep

The JANUS BioTx Pro workstations are compatible with the following modes of purification:

Nexus PhyTips^® columns
Atoll^® RoboColumn^® products
MediaScout^® MiniChrom columns
GraviTrap^® Columns
Resin-filled microtiter vacuum filtration plates

Two models of the JANUS BioTx Pro workstations are available to meet varying requirements

JANUS G3 BioTx Pro Workstation:

12 deck positions
Compact footprint
Flexible control software and wizard driven application assistant
Automated fraction collection station with housing for up to 96 small scale columns

JANUS G3 BioTx Pro Plus Workstation:

24 deck locations
MDT 96 tip head for parallel purification methods
Integrated gripper for labware positioning
Integrated vacuum manifold

Specifications

Precision Automated Pipetting with a Wide Dynamic Volume Range

Pipetting Arm	Volume	% CV	Tip/Head	Condition
Varispan	5 μL 50 μL	<2% <1%	20 μL disposable tip Fixed Tip	Distilled water, 500 μL syringe Distilled water, 500 μL syringe
MDT	1 μL 1 μL 5 μL 50 μL	< 2% < 5%< < 1% < 1%	I20 disposable tip on I50 96-tip Head I20 disposable tip on I50 96-tip Head I235 disposable tips on I235 96-tip Head I235 disposable tips on I235 96-tip Head	1 μL 1 μL 5 μL 50 μL

Pipetting Arm

Volume

% CV

Tip/Head

Condition

Varispan

5 μL

50 μL

<2%

<1%

20 μL disposable tip

Fixed Tip

Distilled water, 500 μL syringe

MDT

1 μL

5 μL

50 μL

< 2%

< 5%<

< 1%

I20 disposable tip on I50 96-tip Head

I235 disposable tips on I235 96-tip Head

1 μL

5 μL

50 μL

Microplate Deck Capacity

JANUS G3 Platform	JANUS G3 BioTx Pro Workstation	JANUS G3 BioTx Pro Plus Workstation
Varispan	9 plates	N/A
Varispan + MDT	N/A	20 plates

JANUS G3 Liquid Handlers Dimensions

Height x Width x Depth

JANUS G3 Instruments Without an Enclosure

Platform	JANUS G3 BioTx Pro Workstation	JANUS G3 BioTx Pro Plus Workstation
Varispan 8-tip	34” (864 mm) x 31” (788 mm) x 33” (838 mm)	N/A
Varispan + MDT	N/A	44” (1118 mm) x 59” (1499 mm) x 33” (838 mm (Includes space requirements for plate::shuttle)