Detect and monitor vascular injury with PerkinElmer’s IVISense™ Vascular Fluorescent Imaging Panel.
This panel of fluorescent imaging probes detects cellular and molecular players in vascular pathology, enabling non-invasive in vivo characterization of biological changes associated with disease progression or treatment efficacy.
For research use only. Not for use in diagnostic procedures.
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Vascular injury can have numerous causes, including peripheral vascular disease, thrombosis, aneurysm, atherosclerosis, and drug induced vascular injury. Vascular injury may progress into changes in vascular integrity, remodeling, inflammation, and fibrosis. This panel of fluorescent imaging probes detects cellular and molecular players in vascular pathology, allowing the ability to non-invasively characterize biological changes associated with disease progression or treatment efficacy.
The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.
The IVISense Vascular Fluorescent Imaging Panel includes the following five probes:
|Part Number||Fluorescent Probe||Biological Target|
|NEV10054EX||IVISense Vascular 680 (AngioSense 680EX)||Vascular probe:
Provides vascular contrast or vascular leak imaging
|NEV10168||IVISense MMP 750 FAST (MMPSense 750 FAST)||Pan-MMP activatable probe:
Secreted protease involved in vascular remodeling and angiogenesis
Secreted by vascular inflammatory cells
|NEV10645||IVISense Integrin Receptor 680 (IntegriSense 680)||αVβ3 integrin targeted probe:
Marker on neovasculature and inflammatory cells involved in vascular inflammation
|NEV11112||IVISense Cat B 680 FAST (Cat B 680 FAST)||Cathepsin B activatable probe:
Lysosomal marker of cells in vascular inflammation
|NEV11171||IVISense Pan Cathepsin 750 FAST (ProSense 750 FAST)||Pan-cathepsin activatable probe:
Lysosomal marker of inflammatory cells in vascular inflammation
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||IVISense|
|Quantity in a Package Amount||5.0 Vials|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Vascular disease|
Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.
Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.
Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.
Learn about several important best practices, from proper probe selection to study design to imaging technique tips and tricks needed to generate meaningful biological information from your in vivo fluorescence imaging studies.
Data sheet on PerkinElmer's Fluorescent Panels for In Vivo imaging
User guide for fluorescent imaging probes
The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.