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Tumors modify the cellular metabolism in cancer cells when compared to normal healthy cells. They alter pathways of nutrient acquisition and metabolism to meet increased energy, synthetic, and proliferative demands. Biomarkers of tumor metabolism offer not only opportunities to study tumor progression but also to specifically assess therapies that target critical pathways in tumor metabolism. Our fluorescent imaging probes provide a variety of tools for quantifying key receptors associated with proliferation and nutrient uptake as well as biomarkers of cell death, protease activity, and vascular leak.
The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.
Our IVISense Tumor Metaolism Fluorescent Imaging Panel includes the following seven probes:
|Part Number||Fluorescent Probe||Biological Target|
|NEV10054EX||IVISense Vascular 680 (AngioSense 680EX)||Vascular probe:
Leaks into sites of edema
|NEV10168||IVISense MMP 750 FAST (MMPSense 750 FAST)||Pan-MMP activatable probe:
Secreted marker of neutrophils, macrophages, and mast cells
|NEV10003||IVISense Pan Cathepsin 680 (ProSense 680)||Pan-cathepsin activatable probe:
Lysosomal marker of a variety of inflammatory cells
|NEV10040||IVISense Folate Receptor 680 (FolateRSense 680)||Folate receptor targeted probe:
Marker on inflammatory cells; metabolic marker on tumor cells
|NEV10090||IVISense Bombesin Receptor 680 (BombesinRSense 680)||Bombesin receptor targeted probe:
Metabolic marker on tumor cells
|NEV10091||IVISense Transferrin Receptor 750 (Transferrin-Vivo 750)||Transferrin receptor targeted probe:
Iron metabolism marker on tumor cells
|NEV11053||IVISense Annexin-V 750 Fluorescent Probe (Annexin-Vivo)||Death/apoptosis probe:
Detects surface phosphatidylserine increase on dying cells
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||IVISense|
|Quantity in a Package Amount||7.0 Vials|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Tumor Metabolism|
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