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Tumors modify the cellular metabolism in cancer cells when compared to normal healthy cells. They alter pathways of nutrient acquisition and metabolism to meet increased energy, synthetic, and proliferative demands. Biomarkers of tumor metabolism offer not only opportunities to study tumor progression but also to specifically assess therapies that target critical pathways in tumor metabolism. Our fluorescent imaging probes provide a variety of tools for quantifying key receptors associated with proliferation and nutrient uptake as well as biomarkers of cell death, protease activity, and vascular leak.
The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.
Our IVISense Tumor Metaolism Fluorescent Imaging Panel includes the following seven probes:
|Part Number||Fluorescent Probe||Biological Target|
|NEV10054EX||IVISense Vascular 680 (AngioSense 680EX)||Vascular probe:
Leaks into sites of edema
|NEV10168||IVISense MMP 750 FAST (MMPSense 750 FAST)||Pan-MMP activatable probe:
Secreted marker of neutrophils, macrophages, and mast cells
|NEV10003||IVISense Pan Cathepsin 680 (ProSense 680)||Pan-cathepsin activatable probe:
Lysosomal marker of a variety of inflammatory cells
|NEV10040||IVISense Folate Receptor 680 (FolateRSense 680)||Folate receptor targeted probe:
Marker on inflammatory cells; metabolic marker on tumor cells
|NEV10090||IVISense Bombesin Receptor 680 (BombesinRSense 680)||Bombesin receptor targeted probe:
Metabolic marker on tumor cells
|NEV10091||IVISense Transferrin Receptor 750 (Transferrin-Vivo 750)||Transferrin receptor targeted probe:
Iron metabolism marker on tumor cells
|NEV11053||IVISense Annexin-V 750 Fluorescent Probe (Annexin-Vivo)||Death/apoptosis probe:
Detects surface phosphatidylserine increase on dying cells
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||IVISense|
|Quantity in a Package Amount||7.0 Vials|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Tumor Metabolism|
Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.
Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.
Learn about several important best practices, from proper probe selection to study design to imaging technique tips and tricks needed to generate meaningful biological information from your in vivo fluorescence imaging studies.
Data sheet on PerkinElmer's Fluorescent Panels for In Vivo imaging
User guide for fluorescent imaging probes
The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.