Transferrin is an important serum protein that mediates iron transport into cells via the transferrin receptor, a function that is essential for cell growth and metabolism.
PerkinElmer’s IVISense™ Transferrin Receptor 750 fluorescent probe (Transferrin-Vivo™) is a NIR-labeled in vivo imaging probe that detects transferrin receptor levels associated with an altered metabolic need for iron in cancer and inflammatory cells. IVISense Transferrin Receptor 750 fluorescent agent also detects normal transferrin receptor levels in the liver as well as decreased expression due to altered iron metabolism associated with drug-induced liver injury.
For research use only. Not for use in diagnostic procedures.
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IVISense Transferrin Receptor 750 is a targeted fluorescent imaging probe, where recombinant transferrin is conjugated to an IVISense fluorescent dye, designed to bind to transferrin receptors (TfRs) expressed in cancer cells. Because of rapid cell division and stringent demand for iron (for heme synthesis), many cancer cell types overexpress TfRs. It has been used as a targeting agent for cancer cells. In addition, TfR accumulates in locals of inflammation due to the leakage of plasma proteins and to the expression of TfR receptors by inflammatory cells. During inflammation monocytes leave the blood and differentiate into macrophages at the extravascular tissues, macrophages express surface Tf receptors.
|Fluorescent Agent Type||Targeted|
|Product Brand Name||IVISense|
|Quantity in a Package Amount||1.0 Units|
|Shipping Condition||Blue Ice|
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