Detect drug induced liver injury (DILI) early in the drug discovery process with PerkinElmer's IVISense™ Toxicology Fluorescent Imaging Panel.
Drug-induced liver injury (DILI) is the leading reason for termination of drug discovery research projects and is a significant concern in attrition of new drug molecules reaching phase III clinical trials. DILI can manifest in hepatocellular, cholestatic, and steatotic forms differing in the type and pattern of tissue injury, biomarker expression and inflammation in the liver lobules.
For research use only. Not for use in diagnostic procedures.
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Our fluorescent imaging probes can allow you to image acute drug-induced biological changes in inflammation, tissue destruction, metabolic changes, and vascular leak (edema) in a manner that predicts the potential for drug toxicity, often prior to overt histological signs.
The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.
Our IVISense Toxicology Fluorescent Imaging Panel includes the following five probes:
| Part Number | Fluorescent Probe | Biological Target |
|---|---|---|
| NEV10054EX | IVISense Vascular 680 (AngioSense 680EX) | Vascular probe: Leaks into sites of vascular damage or inflammation |
| NEV10091 | IVISense Transferrin Receptor 750 (Transferrin-Vivo 750) | Transferrin receptor targeted probe: Iron metabolism marker in liver |
| NEV10168 | IVISense MMP 750 FAST (MMPSense 750 FAST) | Pan-MMP activatable probe: Secreted marker of stellate cells, Kupffer cells, macrophages, and neutrophils |
| NEV11053 | IVISense Annexin-V 750 Fluorescent Probe (Annexin-Vivo) | Death/apoptosis probe: Marker on inflammatory cells; metabolic marker on tumor cells |
| NEV11079 | IVISense Renin 680 FAST (ReninSense 680 FAST) | Renin activatable probe: Marker of tissue renin-angiotensin system activity |
| Optical Imaging Classification | Fluorescence Imaging |
|---|---|
| Product Brand Name | IVISense |
| Quantity in a Package Amount | 5.0 Vials |
| Shipping Condition | Blue Ice |
| Therapeutic Area | Toxicology |
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Data sheet on PerkinElmer's Fluorescent Panels for In Vivo imaging
User guide for fluorescent imaging probes
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IVISense Renin 680 FAST Fluorscent Probe (ReninSense)
List Price : USD887.0
IVISense Annexin-V 750 Fluorescent Probe (Annexin-Vivo)
List Price : USD950.0
IVISense MMP 750 FAST Fluorescent Probe (MMPSense)
List Price : USD871.0
IVISense Transferrin Receptor 750 Fluorescent Probe (Transferrin-Vivo)
List Price : USD752.0
IVISense Vascular 680 Fluorescent Probe (AngioSense)
List Price : USD716.0
