IVISense™ Tomato Lectin 680 fluorescent probe (TLectinSense™) is a NIR labeled macromolecule that targets the vasculature and enables imaging of blood vessels and angiogenesis.
This imaging probe labels endothelial cells and when used in conjunction with optical imaging systems such as PerkinElmer's industry leading IVIS® platform, can be used to non-invasively assess tumor vasculature in response to an anti-angiogenic drug, or to assess vascular burden as another biological consideration.
For research use only. Not for use in diagnostic procedures.
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The protein tomato (L. esculentum) lectin is widely used for vascular labeling because the protein has a high binding affinity for glycoprotein N-acetylglucosamines on the surface of vascular endothelial cells.
IVISense Tomato Lectin 680 is a near-infrared fluorescent imaging probe that is comprised of the tomato lectin protein and a near-infrared fluorophore. This imaging probe targets the vasculature and enables imaging of blood vessels and angiogenesis. It was designed and optimized for use in living animals for assessing vascularity in vivo and in real-time, without termination of mice, excision and processing of the tissue.
Tumors induce significant blood vessel development in order to support their aggressive growth and progression. The extensive and disordered nature of tumor vasculature impairs drug delivery and efficacy. Therefore, destroying the tumor vasculature and/or inhibiting neo-vascularization have become well-accepted and proven cancer treatment strategies. IVISense Tomato Lectin 680 targets the surface of vascular endothelial cells and can be used for quantitation of vascular burden across different tumor cell lines.
|Fluorescent Agent Type||Targeted|
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||IVISense|
|Quantity in a Package Amount||1.0 Units|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Angiogenesis, Oncology/Cancer|
|Unit Size||1 Vial (10 doses)|
|Wave Length||680 nm|
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The protein Tomato (L. esculentum) lectin is widely used for vascular,labeling, because the protein has high binding affinity for glycoprotein N-acetylglucosamines on the surface of vascular endothelial cells. The TLectinSense agent is a near-infrared fluorescent imaging probe designed and optimized ...
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Tumor neo-vasculature, characterized by the development of abnormal, leaky and tortuous blood vessels, represents a key target for cancer imaging and therapy. Among the various recognized tools for measuring microvessel density is tomato (Lycopersicon esculentum) lectin, a single polypeptide glycopr ...
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