PerkinElmer
check quantity

IVISense Neutrophil Elastase 680 FAST Fluorescent Probe

Neutrophil Elastase (NE) is a protease secreted by neutrophils. Neutrophils are the first responders of the innate immune system and play a crucial role in fighting invading pathogens. Thought to be indiscriminate killers, research shows neutrophils are implicated in chronic inflammatory diseases and contribute to injury repair.

Better understand neutrophilic response in vivo with IVISense Neutrophil Elastase 680 FAST NIR fluorescent probe. IVISense Neutrophil Elastase 680 probe can detect NE post-degranulation or netosis from activated neutrophils.

For research use only. Not for use in diagnostic procedures.

Part Number
List Price
Your Price
Quantity
NEV11169
847.00 USD
 
more
Buy Now

Please enter valid quantity

Please log in to add favorites.

NULL OR EMPTY CART

Overview

IVISense Neutrophil Elastase 680 FAST is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with a broader range of early imaging time points. This architecture also offers higher target specific signal with reduced background.

This NIR agent is a neutrophil elastase activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by elastase produced by neutrophil cells. Neutrophil elastase is a key protease involved in acute lung injury, acute respiratory distress syndrome, as well as many other inflammatory processes such as emphysema, cystic fibrosis, COPD, wound healing, rheumatoid arthritis, ischemia-reperfusion and many others.

IVISense Neutrophil Elastase 680 FAST fluorescent imaging agent is a selective neutrophil elastase-activatable agent designed for imaging of this serine protease both in vitro and in vivo. The half-life in plasma of Neutrophil Elastase 680 FAST is 4 hours.

Specifications

Fluorescent Agent Type Activatable
Optical Imaging Classification Fluorescence Imaging
Product Brand Name IVISense
Quantity in a Package Amount 1.0 Units
Shipping Condition Blue Ice
Therapeutic Area Inflammation
Unit Size 1 Vial (10 doses)
Wave Length 680 nm
Resources, Events & More
  • All

Ebook

In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And ...

PDF 4 MB

Flyer

Best Practices for Designing An Effective In Vivo Fluorescence Imaging Study

Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.

Learn about several important best p ...

PDF 507 KB

Guide

IVISense™ Fluorescent Probe Selector Guide for Oncology Research

The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and biological functioning to better understand and characterize disease processes and treatment effects earlier within the context of a biological system.

This s ...

PDF 3 MB

Poster

A novel NIR dye for in vivo temporal tracking of labeled macrophages to sites of acute inflammation

A novel NIR dye for in vivo temporal tracking of labeled macrophages to sites of acute inflammation

PDF 689 KB
Non-Invasive Quantitative Tomography of Disease Progression and Therapeutic Response

We have demonstrated the ability of our Fluorescence Tomography (FMT 2500) in vivo imaging system and ProSense 680 to non-invasively visualize and quantify inflammation in the lung in a robust and validated manner. The consistency of the quantitative tomography, as well as its excellent correlation ...

PDF 581 KB

Technical Note

Neutrophil Elastase 680 FAST (Protocol)

Neutrophil Elastase 680 FAST activatable fluorescent imaging agent Protocol

PDF 257 KB

White Paper

Deciphering the Role of Neutrophils in Virus-Induced Respiratory Disease

Long known as the immune system's first line of defense against bacterial invaders, neutrophils have sparked renewed interest as their proinflammatory response is implicated in the progression and severity of viral diseases, including SARS-CoV-2. As more is learned about their role in respiratory ...

PDF 1 MB
The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick ...

PDF 547 KB