PerkinElmer
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IVISense GFR 680 Fluorescent Probe (GFR-Vivo)

IVISense GFR 680 (GFR-Vivo) is a NIR fluorescent inulin based probe that enables quantitative assessment of renal Glomerular Filtration Rate (GFR), as an indicator of renal toxicity or injury.

For research use only. Not for use in diagnostic procedures.

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Overview

Glomerular filtration rate (GFR) is the gold standard in kidney function assessment and is used to determine progression of kidney disease and drug-induced kidney toxicity. One of the most accepted ways to assess GFR is by measuring the rate of disappearance of labeled inulin from the blood; as inulin is completely filtered at the kidneys’ glomeruli (but neither secreted nor reabsorbed by the tubules), this rate of disappearance is directly proportional to GFR.

Our IVISense GFR 680 fluorescent probe is a labeled form of inulin in a spectral region providing low background and high tissue penetration (ex/em = 670/685 nm) for in vivo applications.

Specifications

Fluorescent Agent Type Vascular
Optical Imaging Classification Fluorescence Imaging
Product Brand Name IVISense
Quantity in a Package Amount 1.0 Units
Shipping Condition Blue Ice
Unit Size 1 Vial (10 doses)
Wave Length 680 nm
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Application Note

In Vivo Non-Invasive Method to Determine Glomerular Filtration Rate (GFR)

An in vivo non-invasive method to determine glomerular filtration rate (GFR). Glomerular filtration rate (GFR) is the gold standard in kidney function assessment and is used to determine progression of kidney disease and drug-induced kidney toxicity. One of the most accepted ways to assess GFR is by ...

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Ebook

In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And ...

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Flyer

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Guide

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The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and biological functioning to better understand and characterize disease processes and treatment effects earlier within the context of a biological system.

This s ...

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Poster

In Vivo NIR Imaging and Quantification of Glomerular Filtration Rate (GFR) in Mice

WMIC2013 Poster_,The measurement of glomerular filtration rate (GFR) is the,gold standard in kidney function assessment and is used to,determine progression of kidney disease and drug-induced,kidney toxicity. This is often assessed indirectly in,preclinical animal models either by surrogate markers, ...

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Novel near Infrared Agent for Noninvasive Imaging and Quantification of Glomerular Filtration Rate in Mice

The measurement of glomerular filtration rate (GFR) is the gold standard in kidney function assessment and is used to determine progression of kidney disease and drug-induced kidney toxicity. GFR has been typically determined in preclinical animal models through measurement of radiolabeled inulin cl ...

PDF 2 MB

White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick ...

PDF 547 KB