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IVISense Gastrointestinal 750 Fluorescent Probe (GastroSense)

IVISense Gastrointestinal 750 (GastroSense 750) is a near-infrared, fluorescently-labeled macromolecule that can be used to monitor the effects of disease or drugs on gastric motility and or gastric emptying. It may also be used as an anatomical marker for the gastrointestinal tract.

For research use only. Not for use in diagnostic procedures.

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Overview

Accurately determining gastric emptying rates is crucial for understanding the physiological mechanisms underlying alterations in gastric motility. Additionally, a pharmacological agent’s effects on gastric emptying can determine its potential as a therapeutic. Currently, the methods used for preclinical determination of gastric emptying rates involve terminal assessment of dye or radioactive tracers within the stomach. These methods require the use of many animals, incurring high financial and time costs. IVISense Gastrointestinal 750 fluorescent probe enables non-invasive in vivo visualization and quantification of the effects of disease or drugs on the GI tract.

Tips:

IVISense Gastrointestinal 750 fluoresscent probe may also be administered as part of a solid diet by applying the reconstituted solution to egg yolk. When added to a solid diet it may be easier to reconstitute the vial of the probe with 300 µL of 1x PBS and use 25 µL per mouse. IVISense Gastrointestinal fluorescent agent remains localized in the GI tract and is not absorbed into the bloodstream.

Specifications

Fluorescent Agent Type Targeted
Optical Imaging Classification Fluorescence Imaging
Product Brand Name IVISense
Quantity in a Package Amount 1.0 Units
Shipping Condition Ambient
Unit Size 1 Vial (10 doses)
Wave Length 750 nm
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Application Note

Gastric Emptying with GastroSense 750

The accurate quantitation of gastric emptying is crucial,for understanding the physiological, pathological and,pharmacological mechanisms underlying gastric motility,both clinically and in animal studies. Current methods,used for determining gastric emptying rates in small animals,are either termina ...

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Ebook

In Vivo Imaging Solutions eBook

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Flyer

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Guide

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Technical Note

GastroSense 750 (Protocol)

GastroSense 750 fluorescent agent imaging protocol outlining procedures for preparing mice for imaging, preparing GastroSense 750 imaging agent, injection agent into mice, and imaging mice on IVIS and/or FMT imaging systems.

PDF 267 KB

White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick ...

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