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IVISense Edema 680 Fluorescent Probe (Superhance)

IVISense Edema (Superhance 680) fluorescent probe is a blood pooling imaging agent for imaging circulation, blood vessels, vasculature, vascular leak, including that associated with early oncologic and ophthalmologic lesions. This agent has a short pharmacokinetic profile with bladder clearance, and binds to albumin in blood for a modestly extended (30m-1h) circulation half-life.

For research use only. Not for use in diagnostic procedures.

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IVISense Edema fluorescent probe is a small molecule near infrared fluorescent probe designed for in vivo preclinical intravenous administration. This probe, being of low molecular weight, will leak and pool in regions of acute edema or vascular leak associated with oncology or other diseases. It is ideal for imaging vascularity, perfusion, and vascular permeability.

Benefits of IVISense Edema 680 fluorescent probe:

  • Small molecule fluorescent in vivo edema and vascular leak imaging agent.
  • Short pharmacokinetic profile, extended modestly by albumin binding moiety to improve performance (30m-1h blood half-life).
  • For imaging of acute changes in vascularity, perfusion, and vascular permeability.
  • Enables sensitive imaging and detection of vascular leak, including that associated with early inflammatory, oncologic, and opthalmologic lesions.


Fluorescent Agent Type Vascular
Optical Imaging Classification Fluorescence Imaging
Product Brand Name IVISense
Quantity in a Package Amount 1.0 Units
Shipping Condition Ambient
Therapeutic Area Vascular disease, Angiogenesis, Inflammation, Oncology/Cancer
Unit Size 1 Vial (10 doses)
Wave Length 680 nm
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Application Note

Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.



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Best Practices for Designing An Effective In Vivo Fluorescence Imaging Study

Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.

Learn about several important best practices, from proper probe selection to study design to imaging technique tips and tricks needed to generate meaningful biological information from your in vivo fluorescence imaging studies.

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Technical Note

Superhance 680 (Data Sheet)

Superhance 680 is a small molecule fluorescent in vivo blood pool imaging agent. Superhance 680 enables imaging of circulation, blood vessels, vasculature, vascular leak, including that associated with early oncologic and opthalmologic lesions.


White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.

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