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IVISense Cat B 680 FAST Fluorescent Probe

IVISense Cat B FAST fluroescent probes enable non-invasive in vivo detection of disease status and progression in oncology, inflammation and other areas associated with Cat B activity.

Associated with tumor aggression, cathepsins are a family of proteases that are pivotal components of signaling pathways that can enhance cancer cell growth and inflammation. Within the human lysosomal cysteine cathepsin family, there are 11 members, including cathepsin B, L, S, and Plasmin. As a family, cysteine cathepsins are involved in the response to anticancer therapy within the tumor microenvironment and play crucial roles in the development of resistance to therapeutics. In particular, cathepsin B expression correlates with the invasive and metastatic capabilities of many tumors, such as in breast cancer where high expression levels of cathepsin B have been linked to highly aggressive tumors. Cathepsin B is also upregulated in a variety of inflammatory cells (including eosinophils, neutrophils, and macrophages).

For research use only. Not for use in diagnostic procedures.

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NEV11112
IVISense Cat B 680 FAST Fluorescent Probe
914.00 USD
 
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NEV11098
IVISense Cat B 750 FAST Fluorescent Probe
888.00 USD
 
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Overview

IVISense Cat B 680 FAST™ is a Cathepsin B activatable fluorescent probe that is optically silent upon injection and produces fluorescent signal after cleavage by Cathepsin B produced by inflammatory cells and tumor cells. IVISense Cat B 680 FAST may be used to monitor inflammation, tumor activity, progression of disease and the efficacy of therapeutic treatment in applications such as oncology, inflammation, cardiovascular disease and some neurological diseases.

IVISense Cat B 680 FAST is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology) that confers an improved pharmacokinetic profile with a broader range of early imaging time points. This architecture also offers higher target-specific signal with reduced background.

Specifications

Fluorescent Agent Type Activatable
Optical Imaging Classification Fluorescence Imaging
Product Brand Name IVISense
Quantity in a Package Amount 1.0 Units
Shipping Condition Ambient
Therapeutic Area Atherosclerosis, Arthritis, Inflammation, Oncology/Cancer
Unit Size 1 Vial (10 doses)
Wave Length 680 nm
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Ebook

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Guide

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Technical Note

Cat B 680 FAST (Protocol)

Cat B™ 680 FAST ( NEV11112) IN VIVO IMAGING PROTOCOL ,

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White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

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