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IVISense Bombesin Receptor 680 fluorescent probe is specific for bombesin receptors (BBRs) expressed in many types of cancer. Bombesin-like peptides and their G-protein coupled receptors have been shown to play a role in cancer and are overexpressed in a variety of tumors, including prostate, breast, lung, CNS, gastric, colon, and renal cell carcinomas.
IVISense Bombesin Receptor 680 imaging agent comprises a 7-amino acid bombesin peptide analog, an NIR fluorophore (ex/em 665/691 nm) and a pharmacokinetic modifier to improve its plasma availability (plasma t1/2 = 30-45 min). This agent can be used to target and quantify upregulation of bombesin receptors (BBR) in vivo associated with tumor proliferation.
|Fluorescent Agent Type||Targeted|
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||IVISense|
|Quantity in a Package Amount||1.0 Units|
|Unit Size||1 Vial (10 doses)|
|Wave Length||680 nm|
BombesinRSense™680 is a fluorescently-labeled peptide designed to bind to bombesin receptors involved in cancer cell stimulation of proliferation.
BombesinRSense 680 in vivo fluorescent imaging agent protocol