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IVISense Annexin-V 750 Fluorescent Probe (Annexin-Vivo)

IVISense Annexin-V 750 fluorescent imaging probe (Annexin-Vivo) is designed to enable in vivo visualization and quantification of membrane-bound phosphatidylserine (PS) during the early stages of apoptosis.

For research use only. Not for use in diagnostic procedures.

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Overview

Annexin A5 (Annexin V) is a cellular protein in the annexin group. Annexin V is a probe commonly used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane.

IVISense Annexin-V 750 is a targeted fluorescent imaging agent comprising the selective protein, Annexin A5 and a near-infrared (NIR) fluorochrome. IVISense Annexin-V 750 enables in vivo visualization and quantification of the membrane-bound phospholipid, phosphotidylserine, exposed in the outer leaflet of the cell membrane lipid bilayer during the early stages of apoptosis.

Specifications

Fluorescent Agent Type Targeted
Optical Imaging Classification Fluorescence Imaging
Product Brand Name IVISense
Quantity in a Package Amount 1.0 Units
Shipping Condition Blue Ice
Therapeutic Area Atherosclerosis, Oncology/Cancer
Unit Size 1 Vial (10 doses)
Wave Length 750 nm
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Application Note

Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed usin ...

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Case Study

A Novel Non-Invasive In Vivo Diagnostic Tool for the Assessment of NASH

Non-alcoholic fatty liver disease (NAFLD) describes a progressive pathology that affects the liver. Fat accumulation causes fatty liver (NAFL) or steatosis to develop, which leads to lipotoxicity and in turn induces liver inflammation and apoptosis, resulting in non-alcoholic steatohepatitis (NAS ...

PDF 963 KB

Ebook

In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And ...

PDF 4 MB

Flyer

Best Practices for Designing An Effective In Vivo Fluorescence Imaging Study

Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.

Learn about several important best p ...

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Guide

IVISense™ Fluorescent Probe Selector Guide for Oncology Research

The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and biological functioning to better understand and characterize disease processes and treatment effects earlier within the context of a biological system.

This s ...

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Poster

Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts

Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more impo ...

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Technical Note

Annexin-Vivo 750 (Protocol)

Protocol for Annexin-Vivo 750 In Vivo Fluorescent Imaging Agent

PDF 257 KB

White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick ...

PDF 547 KB