PerkinElmer
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IVISense 800 NHS Fluorescent Dye (1 mg) (VivoTag)

Label antibodies, small molecules, proteins, or peptides with IVISense NIR fluorescent dyes.

 

PerkinElmer’s IVISense fluorescent dyes (VivoTag®) for labeling antibodies, small molecules, proteins, or peptides are designed specifically to enable customized development of novel superbright fluorescent imaging agents. Dye properties, such as excellent brightness, hydrolytic stability, and photostability, as well as selection for minimal interaction with biological tissue for no potential loss of specificity, have been optimized and validated for use in in vivo or in vitro imaging.

Available as NHS esters or maleimide reactive dyes for conjugation to either free amine (-NH3) or free thiol (-SH) containing molecules. Conjugate an optimal 1-3 dyes onto your protein or choose self-quenching dyes to make your own custom fluorogenic probes.

For research use only. Not for use in diagnostic procedures.

Part Number
SKU Display Name
List Price
Your Price
Quantity
NEV11118
IVISense 680 NHS Fluorescent Labeling Kit (VivoTag)
432.00 USD
 
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NEV11173
IVISense 645 NHS Fluorescent Dye (1 mg) (VivoTag)
191.00 USD
 
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NEV11174
IVISense 645 NHS Fluorescent Dye (5 mg) (VivoTag)
727.00 USD
 
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NEV11119
IVISense 680 NHS Fluorescent Dye (1 mg) (VivoTag)
189.00 USD
 
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NEV11120
IVISense 680 NHS Fluorescent Dye (5 mg) (VivoTag)
721.00 USD
 
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NEV11107
IVISense 800 NHS Fluorescent Dye (1 mg) (VivoTag)
191.00 USD
 
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NEV11108
IVISense 800 NHS Fluorescent Dye (5 mg) (VivoTag)
726.00 USD
 
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NEV11273
IVISense 645 MAL Fluorescent Dye (1 mg) (VivoTag)
200.00 USD
 
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NEV11274
IVISense 645 MAL Fluorescent Dye (5 mg) (VivoTag)
741.00 USD
 
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NEV11219
IVISense 680 MAL Fluorescent Dye (1 mg) (VivoTag)
195.00 USD
 
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NEV11220
IVISense 680 MAL Fluorescent Dye (5 mg) (VivoTag)
741.00 USD
 
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NEV10121
IVISense 680 NHS Fluorescent Self-Quenching Dye (1 mg) (VivoTag)
189.00 USD
 
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NEV10122
IVISense 680 NHS Fluorescent Self-Quenching Dye (5 mg) (VivoTag)
721.00 USD
 
more
NEV10123
IVISense 750 NHS Fluorescent Self-Quenching Dye (1 mg) (VivoTag)
189.00 USD
 
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NEV10124
IVISense 750 NHS Fluorescent Self-Quenching Dye (5 mg) (VivoTag)
721.00 USD
 
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NEV11223
IVISense 750 MAL Fluorescent Self-Quenching Dye (1 mg) (VivoTag)
191.00 USD
 
more
NEV11224
IVISense 750 MAL Fluorescent Self-Quenching Dye (5 mg) (VivoTag)
728.00 USD
 
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Overview

IVISense 800 NHS fluorescent dye is an amine-reactive near infrared (NIR) fluorochrome for coupling via an NHS ester linkage to peptides, small molecules, proteins, antibodies or macromolecules. Unit size 1 mg.

Choose the right IVISense fluorescent dye for your study

Product Abs/Em (nm)  
IVISense NHS FLUORESCENT DYES
IVISense 645 NHS 643/660 Suitable for labeling free amines (typically lysine residues)
IVISense 680 NHS 665/688
IVISense 800 NHS 785/810
IVISense MAL FLUORESCENT DYES
IVISense 645 MAL 643/660 Suitable for labeling free thiols (typically cysteine residues)
IVISense 680 MAL 665/688
IVISense SELF-QUENCHING DYES
IVISense 680 NHS 673/691 When a protein is labeled with multiple IVISense Self-Quenching Dye molecules, there is a shift in the absorbance of the dye, which will reduce the signal. Only choose IVISense Self-Quenching Dyes if your labeling ratio of dye: protein will be 1:1. If multiple dyes are to be conjugated onto your protein, a non-self-quenching IVISense Dye should be used. NHS dyes are suitable for labeling free amines (typically lysine residues), while MAL dyes are suitable for labeling free thiols (typically cysteine residues).
IVISense 750 NHS 750/775
IVISense 750 MAL 750/775

Specifications

Optical Imaging Classification Fluorescence Imaging
Product Brand Name IVISense
Shipping Condition Blue Ice
Unit Size 1 mg
Wave Length 800 nm
Resources, Events & More
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Application Note

VivoTag 800 (Protocol)

VivoTag® 800 is a red fluorescent labeling agent containing an N-hydroxysuccinimide (NHS)-ester. Labeling reagents, such as VivoTag 800 reagent, are commonly used for labeling proteins. The NHS ester moiety reacts with amino groups at pH 7-9 to form stable amide bonds. Lysines within proteins, including antibodies, are available as targets for this chemical conjugation.,Protein labeling efficiency may vary depending upon the type of protein labeled, so different conjugation ratios may need to be attempted to attain success. For Near Infrared fluorophore conjugation, ratios of fluorophore to protein of 4:1 have been seen to generate effective imaging agents. Not all antibodies or proteins (independent of target specificity) make good imaging agents, due to long half-lives and/or excessive accumulation in non-target sites.

PDF 393 KB

Ebook

In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.

PDF 4 MB

Flyer

Best Practices for Designing An Effective In Vivo Fluorescence Imaging Study

Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.

Learn about several important best practices, from proper probe selection to study design to imaging technique tips and tricks needed to generate meaningful biological information from your in vivo fluorescence imaging studies.

PDF 507 KB

Guide

IVISense™ Fluorescent Probe Selector Guide for Oncology Research

The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and biological functioning to better understand and characterize disease processes and treatment effects earlier within the context of a biological system.

This selector guide for IVISense fluorescent probes is a powerful tool to help advance your oncology research. By matching probe properties to specific biology and biomarker characteristics, you can better understand how imaging and quantification of early biological changes associated with disease development, therapeutic efficacy, and drug-induced tissue changes can be realized.

PDF 3 MB

Technical Note

VivoTag® 800 (1 mg) (Data Sheet)

VivoTag® 800 is an amine reactive (NHS Ester) near-infrared (NIR) fluorochrome for labeling biomolecules for in vivo imaging applications.

PDF 154 KB

White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.

PDF 547 KB