PerkinElmer
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IVISbrite Pseudomonas aeruginosa Xen41 Bioluminescent Bacterial Strain

IVISbrite Pseudomonas aeruginosa Xen41 bioluminescent bacteria is derived from parental strain PAO1. For in vitro or in vivo imaging applications, IVISbrite P. aeruginosa-Xen41 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.

For research use only. Not for use in diagnostic procedures.

Part Number 119229
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Overview

Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. PerkinElmer's bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers.

  • Engineered Bacterium: Pseudomonas aeruginosa - Xen41
  • Parental Strain: PAO1
  • In Vitro/Ex Vivo: Growth profiles, Catheter model
  • In Vivo: Biofilm and Pneumonia models

Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:

  • Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well format
  • Sensitivity - subtle changes in cellular viability are rapidly detected
  • Inexpensive - no additional substrates needed for bacterial assays

Advantages of using bioluminescent light-producing microorganisms for drug discovery in vivo:

  • Rapid identification of lead drug candidates
  • Real-time efficacy data
  • May help to decrease drug failure by allowing disease relapse to be monitored in the same animal

Specifications

Gram Positive Gram Negative Gram negative
Luciferase Classification Bacterial luciferase
Optical Imaging Classification Bioluminescence Imaging
Product Brand Name IVISbrite
Shipping Condition Ambient
Therapeutic Area Infectious Diseases
Unit Size 1 agar plate
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