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IVIS Lumina XRMS In Vivo Imaging System

Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.

For Technical Support, visit https://www.perkinelmer.com/contactus#/request-technical-support

Part Number CLS136340
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For research use only. Not for use in diagnostic procedures.

Overview

The Lumina XRMS includes state of the art spectral unmixing for sensitive multispectral imaging to monitor multiple biological events in the same animal. Use our Living Image® software to automate all the controls and settings required for seamless image acquisition and processing. Typical X-ray image acquisitions take only 10 seconds and can be overlaid with both optical and photographic images.

Superior Optical Imaging with Spectral Unmixing

The IVIS Lumina XRMS Series III is capable of imaging all common fluorescent and bioluminescent reporters or dyes. The system is equipped with up to 21 filter sets to image reporters that emit from green to near-infrared. High resolution, sharp cut-off filters are simply interchangeable to achieve the highest performance, sensitivity and spectral unmixing. The Lumina XRMS imaging system also accommodates Petri dishes or micro-titer plates for in vitro imaging.

The system can incorporate premium animal handling features such as a heated stage, gas anesthesia connections and a syringe injection system for simultaneous compound administration. Living Image software yields high-quality, reproducible, quantitative results incorporating instrument calibration, background subtraction and the image algorithms. Simple user guided spectral unmixing allows detection and separation of multiple reporters, and Living Image provides the precise overlay to see your optical reporters together with anatomical surface or X-ray features.

Features and Benefits:

  • Multispecies optical and X-ray imaging
  • Image mice, rats and other large animals
  • High resolution, low dose digital X-Ray
  • Exquisite sensitivity in bioluminescence
  • Compute Pure Spectrum (CPS) spectral unmixing for ultimate fluorescence sensitivity
  • Full fluorescence tunability through the NIR Spectrum

Selected Publications

  • Zhang et al (2021). One-step and facile synthesis of peptide-like poly(melphalan) nanodrug for cancer therapy. Nanotoday. 37; 101098. https://doi.org/10.1016/j.nantod.2021.101098
  • Zou et al (2020). A ZIF-90 nanoplatform loaded with an enzyme-responsive organic small-molecule probe for imaging the hypoxia status of tumor cells. Nanoscale. 12, 14870-14881. https://doi.org/10.1039/D0NR02580A
  • Parkins et al (2020). Engineering Circulating Tumor Cells as Novel Cancer Theranostics. Theranostics. 10(17): 7925–7937. https://dx.doi.org/10.7150%2Fthno.44259
  • Son et al (2019). Gelatin–chlorin e6 conjugate for in vivo photodynamic therapy. J Nanobiotechnology. 17(50). https://doi.org/10.1186/s12951-019-0475-1
  • Wang et al (2019). A Y1 receptor ligand synergized with a P-glycoprotein inhibitor improves the therapeutic efficacy of multidrug resistant breast cancer. Biomater. Sci., 7, 4748-4757.https://doi.org/10.1039/C9BM00337A
  • Gao et al (2018). A unique off-on near-infrared cyanine-based probe for imaging of endogenous alkaline phosphatase activity in cells and in vivo. Sensors & Actuators: Chemical. 265: 565-574. https://doi.org/10.1016/j.snb.2018.03.078
  • Shen et al (2018). Versatile hyaluronic acid modified AQ4N-Cu(II)-gossypol infinite coordination polymer nanoparticles: Multiple tumor targeting, highly efficient synergistic chemotherapy, and real-time self-monitoring. Biomaterials. 154: 197-212. https://doi.org/10.1016/j.biomaterials.2017.11.001
  • Gong et al (2018). A Ultrasensitive Near‐Infrared Fluorescent Probe Reveals Pyroglutamate Aminopeptidase 1 Can Be a New Inflammatory Cytokine. Adv Scihttps://doi.org/10.1002/advs.201700664
  • Lai et al (2016). Fluorescent gold nanoclusters for in vivo target imaging of Alzheimer's disease. RSC Advances. 6, 30081-30088. https://doi.org/10.1039/C6RA01027J
  • Zhao et al (2016). In vivo target bio-imaging of cerebral ischemic stroke by real-time labeling of zinc. RSC Adv., 2016,6, 110525-110534. https://doi.org/10.1039/C6RA23507G

For additional publications, please visit Google Scholar.

Specifications

Height 104.0 cm
Imaging Modality Optical Imaging
Optical Imaging Classification Bioluminescence imaging, Fluorescence Imaging
Portable No
Product Brand Name IVIS
Width 48.0 cm
Resources, Events & More
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Application Note

Cerenkov Imaging of Radioisotopes in IVIS systems

Cerenkov Emission from radioisotopes in tissue,Optical imaging detects photons in the visible range of the electromagnetic,spectrum. PET and SPECT imaging instruments are sensitive to photons in the much,higher energy range of x-rays and gamma rays. While the PET and SPECT probes,which can generate ...

PDF 2 MB
Imaging Oncolytic Virus Infection in Cancer Cells

Aside from the traditional small-molecule chemotherapeutics or targeted therapy agents that have been widely used in the clinic for decades, a new type of cancer therapeutics based on oncolytic viruses has recently gained attention in the field of research. Oncolytic viruses are genetically modif ...

PDF 2 MB
Stem Cell Research and Regenerative Medicine

With the potential to treat a wide range of disease, from organ damage to congenital defects, stem cell research and tissue engineering form the underlying basis of regenerative medicine. Significant advances in the science of skin regeneration, for example, have now made it possible to develop and ...

PDF 1 MB

Case Study

Tracking Neuroinflammation Using Transgenic Mouse Models and Optical Imaging

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease for which there is no cure. Another lethal brain disease is stroke, which occurs when blood supply to the brain is disrupted by a blood vessel that bursts or becomes blocked. Neuroinflammation plays a key role in both of th ...

PDF 1 MB
A Novel Mouse Model Using Optical Imaging to Detect On-Target, Off-Tumor CAR-T Cell Toxicity

CAR T therapy has achieved tremendous success in treating blood malignancies, however treating solid tumors with this therapy has proven to be challenging due to several factors such as on-tumor, off-tumor toxicity.

Read this case study where researchers from University of Pennsylvania crea ...

PDF 1 MB
A Novel Non-Invasive In Vivo Diagnostic Tool for the Assessment of NASH

Non-alcoholic fatty liver disease (NAFLD) describes a progressive pathology that affects the liver. Fat accumulation causes fatty liver (NAFL) or steatosis to develop, which leads to lipotoxicity and in turn induces liver inflammation and apoptosis, resulting in non-alcoholic steatohepatitis (NAS ...

PDF 963 KB
Using IVIS optical imaging of CRISPR/Cas9 engineered adipose tissue to study obesity prevention

Obesity is a global epidemic that is the fifth leading cause of death worldwide and in the US alone, nearly 85% of adults are expected to be overweight or obese by 2030. In addition to the increased risk of overall mortality, obesity is associated with an increased risk for other metabolic disord ...

PDF 1 MB

Ebook

In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And ...

PDF 4 MB

Flyer

Best Practices for Designing An Effective In Vivo Fluorescence Imaging Study

Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.

Learn about several important best p ...

PDF 507 KB

Guide

IVISense™ Fluorescent Probe Selector Guide for Oncology Research

The goal of in vivo fluorescence molecular imaging is to enable non-invasive visualization and quantification of cellular and biological functioning to better understand and characterize disease processes and treatment effects earlier within the context of a biological system.

This s ...

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Product Note

IVIS Lumina XRMS Series III Product Note

IVIS Lumina XR Series III Integrating Gold Standard Bioluminescence, Fluorescence and X-Ray In Vivo Technologies. The IVIS Lumina XR Series III from PerkinElmer provides an expandable, sensitive imaging system that is easy to use for fluorescent, bioluminescent, radioistopic and X-Ray imaging in viv ...

PDF 1 MB

Publication Review

In Vivo Imaging of Influenza Virus Infection in Immunized Mice

Influenza is a highly infectious airborne disease with an important societal burden. Annual epidemics have occurred throughout history causing tens of millions of deaths. Even a run-of-the-mill influenza infection can be debilitating to otherwise healthy people, and lethal to those who are elderl ...

PDF 436 KB
Applications of In Vivo Bioluminescence Imaging for SARS-CoV-2

Scientists continue to explore several options to treat SARS-CoV-2 infection with hundreds of therapeutics at various phases of development. At the start of the pandemic, several factors hampered the rapid identification of potential SARS-CoV-2 therapeutics, including a limited understanding of t ...

PDF 918 KB
Clinically translatable cytokine delivery platform for eradication of intraperitoneal tumors

Proinflammatory cytokine interleukin-2 (IL-2) is of particular interest for cancer immunotherapy as it plays a critical role in the regulation of immune cells such as T cells. Although proinflammatory cytokines have been used to treat various cancers including metastatic melanoma and renal carcin ...

PDF 258 KB
Evaluating a Novel Nanoparticle Platform for Controlled Liraglutide Release in a Type II Diabetes Mouse Model Via Optical Imaging

A large percentage of Type 2 diabetes mortality is related to cardiovascular complications. Consequently, there is a critical need for creating novel therapeutics that not only manage blood glucose levels, but also reduce the risk of developing cardiovascular diseases.

Liraglutide (Lira) is ...

PDF 538 KB

Software Downloads

Technical Note

PDF 607 KB
PDF 1 MB
High Resolution Images

Acquisition of High Resolution Images. This quick reference guide is for those researchers who wish to perform analysis that requires high resolution including in vitro studies when one may want to discern aspects about cell layers, ex vivo tissue imaging, or imaging of tissue slices. You will not ...

PDF 1 MB
Image Overlay 2D

Not only is it possible to load multiple images as a group, for example multiple days of a longitudinal study, but it is also possible to load multiple images and Overlay them i.e. bioluminescent tumor with fluorescent targeted drug acquired in two separate images.

PDF 472 KB
Loading Groups of Images

For many studies, it may be desirable to open a group of images together, for example, analyzing multiple days of longitudinal study side by side using the same scale.

PDF 751 KB
Subject ROI

Subject ROI using IVIS imaging systems

PDF 2 MB
Working with Image Math

Working with Image Math. Image Math is a rudimentary but effective method for Spectrum and Lumina users to subtract background from images without performing Spectral Unmixing.

PDF 911 KB

Video Article

Webinars

White Paper

Bioluminescence Resonance Energy Transfer (BRET) to Monitor Protein-Protein Interactions

The ability to image protein-protein interactions (PPIs) in vivo has important implications for a wide variety of biological research endeavors, including drug discovery and molecular medicine. The visual representation, characterization, quantification, and timing of these biological proc ...

PDF 1 MB
Non-Invasive Optical Imaging for Viral Research and Novel Therapeutic and Vaccine Development

Viral diseases have emerged and re-emerged throughout history, and as the human population continues to increase globally, so will the frequency of viral pandemics. Not only have Ebola and COVID-19 demonstrated most recently mankind’s vulnerability to contagious diseases, but also the challenges ...

PDF 2 MB
The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick ...

PDF 547 KB