PerkinElmer
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IVISense Integrin Receptor 750 Fluorescent Probe (IntegriSense)

Integrins are a superfamily of transmembrane cell surface receptors that mediate signal transduction, cell-to-cell interaction, and cell-to-extracellular matrix adhesion - key processes for healthy cells as well as progression of disease states such as atherosclerosis and cancer, where integrins contribute to angiogenesis, tumorigenesis, and metastasis.

Among this superfamily, αvβ3 integrin holds promise as a therapeutic target in areas such as immuno-oncology, where αvβ3 integrin may prevent tumors from evading the immune system. PerkinElmer's IVISsense Integrin Receptor fluorescent probes (IntegriSense) are designed to target αvβ3 integrin for monitoring tumor growth, angiogenesis and assessing treatment efficacy.

For research use only. Not for use in diagnostic procedures.

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NEV10640
IVISense Integrin Receptor 645 Fluorescent Probe (IntegriSense)
778.00 USD
 
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NEV10645
IVISense Integrin Receptor 680 Fluorescent Probe (IntegriSense)
764.00 USD
 
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NEV10873
IVISense Integrin Receptor 750 Fluorescent Probe (IntegriSense)
764.00 USD
 
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Overview

IVISense Integrin Receptor 750 fluorescent imaging probe for in vivo detection of αvβ3 integrin is a low molecular weight peptidomimetic antagonist coupled to a red fluorochrome. This validated, high affinity (Kd = 4.2 nM) fluorescent probe has improved circulation half-life and specificity over RDG peptide-based agents, with selectivity 5-20x for αvβ3 integrin, for precise detection of αvβ3 integrins. This integrin-targeted molecular imaging agent enables non-invasive imaging to better understand biological processes, and disease biology and progression.

Including IVISense Integrin Receptor 750 fluorescent agent in careful experimental design allows for multiplexing with other channels and/or imaging times, and can be paired with other probes to achieve maximum efficiency and flexibility in your imaging studies.

Specifications

Fluorescent Agent Type Targeted
Optical Imaging Classification Fluorescence Imaging
Product Brand Name IVISense
Quantity in a Package Amount 1.0 Units
Shipping Condition Blue Ice
Therapeutic Area Angiogenesis, Atherosclerosis, Oncology/Cancer
Unit Size 1 Vial (10 doses)
Wave Length 750 nm
Resources, Events & More
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Application Note

In Vivo Imaging of Atherosclerosis Disease Using FMT

Current means of measuring disease in preclinical models of atherosclerosis include ex vivo assessment of disease tissues post-mortem and non-invasive imaging primarily of structural and anatomic features of lesions, in vivo. A non-invasive, quantitative means of imaging known biologic profiles associated with atherosclerotic disease, in vivo, would enable a robust additional understanding and analysis of disease progression and therapeutic response in research and drug development. We report the utility of the near infrared (NIR) protease-sensing, ProSense® 750 Fluorescent Pre-clinical Imaging Agent, in combination with the FMT® 2500 Quantitative Pre-clinical Imaging System for the non-invasive quantitative measurement of atherosclerotic disease biology and related response to therapy in apolipoprotein (apo) E-deficient mice in vivo. FMT (Fluorescence Molecular Tomography) imaging measured significant increases in aortic region protease activity with a range of values that were comparable to the range seen in the ex vivo aortic arches assessed by fluorescence reflectance imaging (FRI).

PDF 1 MB
Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

PDF 4 MB

Ebook

In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.

PDF 4 MB

Flyer

Best Practices for Designing An Effective In Vivo Fluorescence Imaging Study

Fluorescence molecular imaging is the visualization of cellular and biological function in vivo to gain deeper insights into disease processes and treatment effects. Designing an effective study from the beginning can help save time and resources.

Learn about several important best practices, from proper probe selection to study design to imaging technique tips and tricks needed to generate meaningful biological information from your in vivo fluorescence imaging studies.

PDF 507 KB
Integrins as targets for Immunotherapy

Integrins are a superfamily of transmembrane cell surface receptors that mediate signal transduction, cell-to-cell interaction, and cell-to-extracellular matrix adhesion - key processes for healthy cells as well as in the progression of disease states such as cancer.

Among this superfamily, αvβ3 integrin holds promise as a therapeutic target in areas such as immuno-oncology, where it may enable tumors to evade the immune system. PerkinElmer's IntegriSense fluorescent probes are designed to target αvβ3 integrin to help researchers better understand how cancer cells hijack normal integrin-related cell signaling and cell adhesion processes that promote tumor growth and metastases, as well as investigating the potential of integrin-blocking cancer immunotherapies.

PDF 1 MB

Technical Note

IntegriSense 750 (Protocol)

IntegriSense 750 in vivo fluorescent agent protocol

PDF 258 KB
IntegriSense™ 750 (Data Sheet)

IntegriSense™ 750 is a targeted fluorescence imaging agent comprising a potent, selective non-peptide small molecule integrin avß3 antagonist and a near-infrared (NIR) fluorochrome. This agent has been developed to enable in vivo visualization and quantification of integrin avß3 expressed in tumor cells as well as in neovasculature, to monitor tumor growth, tumor angiogenesis, and treatment efficacy.

PDF 57 KB

White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.

PDF 547 KB