Integrins are transmembrane cell surface receptors which mediate signal transduction, cell-to-cell interaction and cell-to extracellular matrix adhesion, key processes involved in angiogenesis, tumorigenesis and metastasis. Integrins have thus been hailed as clinically-relevant biomarkers of pathological conditions such as inflammation and tumor progression. The integrin avb3 is significantly upregulated in tumor cells and activated endothelial cells during neoangiogenesis.
IntegriSense™ 680 fluorescent imaging agent is used for in vivo detection of avb3 using a low molecular weight peptidomimetic antagonist coupled to a red fluorochrome. IntegriSense 680, an integrin-targeted molecular imaging agent allows the non-invasive imaging of disease status and progression. Pairing of an integrin antagonist treatment with IntegriSense 680 provides a mechanistic biomarker approach for assessing target coverage.
Disclaimer: For laboratory use only. This product is intended for animal research only and not for use in humans.
|Fluorescent Agent Type||Targeted|
|Optical Imaging Classification||Fluorescence Imaging|
|Product Brand Name||IntegriSense|
|Quantity in a Package Amount||1.0 Units|
|Therapeutic Area||Angiogenesis, Atherosclerosis, Oncology/Cancer|
|Unit Size||1 Vial (10 doses)|
|Wave Length||680 nm|
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|Resource Type||File Name||File Format|
|Brochure||In Vivo Imaging Agents Brochure||PDF 2 MB|
|Application Note||In Vivo Imaging of Atherosclerosis Disease Using FMT||PDF 1 MB|
|Technical Note||IntegriSense 680 (Protocol)||PDF 257 KB|
|Technical Note||IntegriSense™ 680 (Data Sheet)||PDF 52 KB|
|Poster||In Vivo Quantification of Integrin-Targeted and Protease-Activated Imaging Agents inResponse to Anti-Angiogenic Therapy using Quantitative Fluorescence Tomography Near Infrared-Labeled Agent and Fluorescence Molecular Tomography (FMT)||PDF 385 KB|
|Poster||Near-Infrared Fluorescence Imaging and Quantification of Anti-Angiogenic Therapy||PDF 509 KB|
|Poster||Quantitative Tomographic In Vivo Imaging of Syngeneic Breast Cancer Metastasis to the Lung and Therapeutic Response||PDF 610 KB|
|Citations Library||View peer reviewed publications using PerkinElmer's In Vivo Imaging Reagents||Link|
|Webinars||View our complete list of in vivo webinars available on demand||Link|