For research use only. Not for use in diagnostic procedures.
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Vascular injury can have numerous causes, including peripheral vascular disease, thrombosis, aneurysm, atherosclerosis, and drug induced vascular injury. Vascular injury may progress into changes in vascular integrity, remodeling, inflammation, and fibrosis. This panel of fluorescent imaging probes detects cellular and molecular players in vascular pathology, allowing the ability to non-invasively characterize biological changes associated with disease progression or treatment efficacy.
The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.
The Vascular In Vivo Fluorescent Agents Panel includes the following five probes:
|Part Number||Fluorescent Probe||Biological Target|
|NEV10054EX||AngioSense 680 EX||Vascular probe:
Provides vascular contrast or vascular leak imaging
|NEV10168||MMPSense 750 FAST||Pan-MMP activatable probe:
Secreted protease involved in vascular remodeling and angiogenesis
Secreted by vascular inflammatory cells
|NEV10645||IntegriSense 680||αVβ3 integrin targeted probe:
Marker on neovasculature and inflammatory cells involved in vascular inflammation
|NEV11112||Cat B 680 FAST||Cathepsin B activatable probe:
Lysosomal marker of cells in vascular inflammation
|NEV11171||ProSense 750 FAST||Pan-cathepsin activatable probe:
Lysosomal marker of inflammatory cells in vascular inflammation
|Optical Imaging Classification||Fluorescence Imaging|
|Quantity in a Package Amount||5.0 Units|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Vascular disease|
|Unit Size||1 vial|
Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.
User guide for fluorescent imaging probes
The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.