PerkinElmer
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Fluorescent Imaging Agent Panel – Vascular

Detect and monitor vascular injury with PerkinElmer’s In Vivo Fluorescent Imaging Agents Panel.

For research use only. Not for use in diagnostic procedures.

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NEV20014
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Overview

Vascular injury can have numerous causes, including peripheral vascular disease, thrombosis, aneurysm, atherosclerosis, and drug induced vascular injury. Vascular injury may progress into changes in vascular integrity, remodeling, inflammation, and fibrosis. This panel of fluorescent imaging probes detects cellular and molecular players in vascular pathology, allowing the ability to non-invasively characterize biological changes associated with disease progression or treatment efficacy.

The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.


The Vascular In Vivo Fluorescent Agents Panel includes the following five probes:

Part Number Fluorescent Probe Biological Target
NEV10054EX AngioSense 680 EX Vascular probe:
Provides vascular contrast or vascular leak imaging
NEV10168 MMPSense 750 FAST Pan-MMP activatable probe:
Secreted protease involved in vascular remodeling and angiogenesis
Secreted by vascular inflammatory cells
NEV10645 IntegriSense 680 αVβ3 integrin targeted probe:
Marker on neovasculature and inflammatory cells involved in vascular inflammation
NEV11112 Cat B 680 FAST Cathepsin B activatable probe:
Lysosomal marker of cells in vascular inflammation
NEV11171 ProSense 750 FAST Pan-cathepsin activatable probe:
Lysosomal marker of inflammatory cells in vascular inflammation

Specifications

Optical Imaging Classification Fluorescence Imaging
Quantity in a Package Amount 5.0 Units
Shipping Condition Blue Ice
Therapeutic Area Vascular disease
Unit Size 1 vial
Resources, Events & More
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Application Note

Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

PDF 4 MB

Ebook

In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.

PDF 4 MB

Flyer

Fluorescent Panels Targeted for Your Research

Data sheet on PerkinElmer's Fluorescent Panels for In Vivo imaging

PDF 838 KB

Guide

Fluorescent Imaging Panels (User Guide)

User guide for fluorescent imaging probes

PDF 800 KB

White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.

PDF 748 KB