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Fluorescent Imaging Agent Panel – Tumor Metabolism

Advance your understanding of cancer using PerkinElmer’s In Vivo Fluorescent Agents Panel specific for measuring and detecting tumor metabolism in vivo.

For research use only. Not for use in diagnostic procedures.

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Tumors modify the cellular metabolism in cancer cells when compared to normal healthy cells. They alter pathways of nutrient acquisition and metabolism to meet increased energy, synthetic, and proliferative demands. Biomarkers of tumor metabolism offer not only opportunities to study tumor progression but also to specifically assess therapies that target critical pathways in tumor metabolism. Our fluorescent imaging probes provide a variety of tools for quantifying key receptors associated with proliferation and nutrient uptake as well as biomarkers of cell death, protease activity, and vascular leak.

The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.


The Tumor Metabolism In Vivo Fluorescent Agents Panel includes the following seven probes:

Part Number Fluorescent Probe Biological Target
NEV10054EX AngioSense 680 EX Vascular probe:
Leaks into sites of edema
NEV10168 MMPSense 750 FAST Pan-MMP activatable probe:
Secreted marker of neutrophils, macrophages, and mast cells
NEV10003 ProSense 680 Pan-cathepsin activatable probe:
Lysosomal marker of a variety of inflammatory cells
NEV10040 FolateRSense 680 Folate receptor targeted probe:
Marker on inflammatory cells; metabolic marker on tumor cells
NEV10090 BombesinRSense 680 Bombesin receptor targeted probe:
Metabolic marker on tumor cells
NEV10091 Transferrin-Vivo 750 Transferrin receptor targeted probe:
Iron metabolism marker on tumor cells
NEV11053 Annexin-Vivo 750 Death/apoptosis probe:
Detects surface phosphatidylserine increase on dying cells


Optical Imaging Classification Fluorescence Imaging
Quantity in a Package Amount 7.0 Units
Shipping Condition Blue Ice
Therapeutic Area Tumor Metabolism
Unit Size 1 vial
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In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.



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Data sheet on PerkinElmer's Fluorescent Panels for In Vivo imaging

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User guide for fluorescent imaging probes

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White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.

PDF 547 KB