PerkinElmer
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Fluorescent Imaging Agent Panel – Toxicology

Detect drug induced liver injury (DILI) early in the drug discovery process with PerkinElmer’s Toxicology Fluorescent Imaging Agent Panel.

For research use only. Not for use in diagnostic procedures.

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NEV20016
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Overview

Drug-induced liver injury (DILI) is the leading reason for termination of drug discovery research projects and is a significant concern in attrition of new drug molecules reaching phase III clinical trials. DILI can manifest in hepatocellular, cholestatic, and steatotic forms differing in the type and pattern of tissue injury, biomarker expression and inflammation in the liver lobules. Our fluorescent imaging probes can allow you to image acute drug-induced biological changes in inflammation, tissue destruction, metabolic changes, and vascular leak (edema) in a manner that predicts the potential for drug toxicity, often prior to overt histological signs.

The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.


The Toxicology In Vivo Fluorescent Agents Panel includes the following five probes:

Part Number Fluorescent Probe Biological Target
NEV10054EX AngioSense 680 EX Vascular probe:
Leaks into sites of vascular damage or inflammation
NEV10091 Transferrin-Vivo 750 Transferrin receptor targeted probe:
Iron metabolism marker in liver
NEV10168 MMPSense 750 FAST Pan-MMP activatable probe:
Secreted marker of stellate cells, Kupffer cells, macrophages, and neutrophils
NEV11053 Annexin-Vivo 750 Death/apoptosis probe:
Marker on inflammatory cells; metabolic marker on tumor cells
NEV11079 RenninSense 680 FAST Renin activatable probe:
Marker of tissue renin-angiotensin system activity

Specifications

Optical Imaging Classification Fluorescence Imaging
Quantity in a Package Amount 6.0 Units
Shipping Condition Blue Ice
Therapeutic Area Toxicology
Unit Size 1 vial
Resources, Events & More
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Ebook

In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.

PDF 4 MB

Flyer

Fluorescent Panels Targeted for Your Research

Data sheet on PerkinElmer's Fluorescent Panels for In Vivo imaging

PDF 838 KB

Guide

Fluorescent Imaging Panels (User Guide)

User guide for fluorescent imaging probes

PDF 800 KB

White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.

PDF 748 KB