For research use only. Not for use in diagnostic procedures.
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Inflammation is a complex biological response to stimuli presented by pathogens, tissue damage, or local irritants and involves a variety of immune cells that work to remove and repair the original insult and damaged tissue regions. Our fluorescent imaging probes provide a variety of tools for quantifying inflammatory biology (various proteases or upregulated receptors) as well as detecting and measuring the edema response. The ability to non-invasively quantify inflammation biology in vivo offers greater opportunity for longitudinal studies and understanding disease pathogenesis in the context of intact animal physiology.
The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.
The Inflammation In Vivo Fluorescent Agents Panel includes the following six probes:
|Part Number||Fluorescent Probe||Biological Target|
|NEV10054EX||AngioSense 680 EX||Vascular probe:
Leaks into sites of edema
|NEV10168||MMPSense 750 FAST||Pan-MMP activatable probe:
Secreted marker of neutrophils, macrophages, and mast cells
|NEV10040||FolateRSense 680||Folate receptor targeted probe:
Marker on activated neutrophils and macrophages
|NEV10873||IntegriSense 750||αVβ3 integrin targeted probe:
Marker on activated macrophages
|NEV11169||Neutrophil Elastase 680 FAST||Neutrophil elastase activatable probe:
Secreted protease from neutrophils
|NEV11171||ProSense 750 FAST||Pan-cathepsin activatable probe:
Lysosomal marker of a variety of inflammatory cells
|Optical Imaging Classification||Fluorescence Imaging|
|Quantity in a Package Amount||6.0 Units|
|Shipping Condition||Blue Ice|
|Unit Size||1 vial|
Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.
User guide for fluorescent imaging probes
The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.