For research use only. Not for use in diagnostic procedures.
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PerkinElmer has developed a number of important fluorescence reagents that allow imaging of a variety of disease or biological models. Our most popular probes have been selected based on the important biomarkers they target. These probes, ProSense 680, AngioSense 680EX, FolateRSense 680, MMPSense 750 FAST, and IntegriSense 750, show broad utility in a number of applications, including cancer, angiogenesis, arthritis, cardiovascular disease, and acute inflammation. In addition, PerkinElmer’s VivoTag 680XL fluorophore provides a useful, in vivo-optimized fluorescent label for researchers to tag their own proteins, peptides, or antibodies as either imaging tools or for assessing protein/antibody biodistribution.
The availability of probes at 680 nm and 750 nm wavelengths further offers the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.
The Featured Probe Pack In Vivo Fluorescent Agents Panel includes the following six probes:
|Part Number||Fluorescent Probe||Biological Target|
|NEV10003||ProSense 680||Pan-cathepsin activatable probe:
Lysosomal marker of inflammatory cells and tumor cells
|NEV10054EX||AngioSense 680 EX||Vascular probe:
Leaks into sites of edema/cancer
|NEV10040||FolateRSense 680||Folate receptor targeted probe:
Marker on inflammatory cells; metabolic marker on tumor cells
|NEV10168||MMPSense 750 FAST||Pan-MMP activatable probe:
Secreted marker of inflammatory cells, fibrosis, and tumor margins
|NEV10873||IntegriSense 750||αVβ3 integrin targeted probe:
Marker on tumors, neovasculature, and osteoclasts
|NEV11118||VivoTag 680XL Protein Labeling Kit||NIR fluorescence labeling kit:
Labeling antibodies, proteins, and peptides for in vivo imaging
|Optical Imaging Classification||Fluorescence Imaging|
|Quantity in a Package Amount||6.0 Units|
|Shipping Condition||Blue Ice|
|Unit Size||1 vial|
Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.
User guide for fluorescent imaging probes
The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.