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Fluorescent Imaging Agent Panel – Arthritis

Detect molecular players in arthritis pathology with PerkinElmer’s In Vivo Arthritis Fluorescent Imaging Agent Panel.

For research use only. Not for use in diagnostic procedures.

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The biology of arthritis is complex, involving multiple cellular players, secreted factors, and processes that can lead to sever joint damage. Our fluorescent imaging probes targeting arthritis research allows in vivo imaging of the magnitude of inflammation, bone destruction, cartilage degradation, and vascular leak (edema) in a manner that non-invasively predicts the underlying histopathology of this disease.

The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.


The Arthritis In Vivo Fluorescent Agents Panel includes the following six probes:

Part Number Fluorescent Probe Biological Target
NEV10003 ProSense 680 Pan-cathepsin activatable probe:
Lysosomal marker of inflammatory cells
NEV10011EX AngioSense 750 EX Vascular probe:
Leaks into sites of edema
NEV10020EX OsteoSense 680 EX Bone turnover targeted probe:
Detects areas of exposed hydroxyapatite
NEV10126 MMPSense 680 Pan-MMP activatable probe:
Secreted marker of inflammatory cells, bone/cartilage degradation
NEV11000 CAT K 680 FAST Cathepsin K activatable probe:
Secreted marker of osteoclasts, bone degradation
NEV11098 CAT B 750 FAST Cathepsin B activatable probe:
Lysosomal marker of inflammatory cells


Optical Imaging Classification Fluorescence Imaging
Quantity in a Package Amount 6.0 Units
Shipping Condition Blue Ice
Therapeutic Area Arthritis
Unit Size 1 vial
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In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.



Fluorescent Panels Targeted for Your Research

Data sheet on PerkinElmer's Fluorescent Panels for In Vivo imaging

PDF 838 KB


Fluorescent Imaging Panels (User Guide)

User guide for fluorescent imaging probes

PDF 800 KB

White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.

PDF 547 KB