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Membrane Target Systems: Prokineticin PKR2 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Prokineticin PKR2 receptor, in HEK-293 cells.

Some of our receptors may be restricted for sale in specified countries. Please inquire.

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Membrane Target Systems are quality assured frozen membranes from cells that express recombinant or endogenous receptors.

We submit every batch of receptor to stringent quality control
testing that includes saturation radioligand binding assay to determine receptor concentration (Bmax) and affinity (Kd). Competition binding assays are performed determine affinity (Ki) against known reference agonists and antagonists. GTPγS data is also provided for some of our Gi-coupled receptors.

Membranes are carefully prepared and ready for a variety of HTS applications, including radioligand binding (using either proximitymethods, such as FlashPlate, or classical filtration methods).

Products are packaged as frozen crude membrane preparations. One assay unit is defined as micrograms of protein, defined by competition binding assay (filtration). A complete product description and recommended protocol are included on the Product Information Sheet.

Some of our receptors may be restricted for sale in specified countries. Please inquire.


Assay Target Class GPCR
Assay Target Type Membrane preparation
Assay Validated Binding
G-Alpha Natural Receptor Gq/G11
Host Cell HEK293
Product Brand Name Membrane Target Systems
Receptor Type Prokineticin
Shipping Condition Dry Ice
Unit Size 400 units
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Product Note

Prokineticin-2 (PKR2) Receptor (Human, Recombinant)

The human Prokineticin-2 receptor, also named GPR73L1, GPR73b and I5E, was cloned in 2002 from a pooled testis and fetal brain cDNA library (Lin et al.). In the same year, tissue distribution studies of this receptor were performed by Soga et al., showing a very high level in the fetal brain. The two groups also cloned the human Prokineticin-1 receptor, which shares 85% overall sequence identity with the PKR2 receptor.