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Membrane Target Systems: Neurotensin NTS1 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Neurotensin NTS1 receptor, in HEK-293 cells.

Some of our receptors may be restricted for sale in specified countries. Please inquire.

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RBXNT1M400UA
1429.00 USD
 
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Overview

Membrane Target Systems are quality assured frozen membranes from cells that express recombinant or endogenous receptors.

We submit every batch of receptor to stringent quality control
testing that includes saturation radioligand binding assay to determine receptor concentration (Bmax) and affinity (Kd). Competition binding assays are performed determine affinity (Ki) against known reference agonists and antagonists. GTPγS data is also provided for some of our Gi-coupled receptors.

Membranes are carefully prepared and ready for a variety of HTS applications, including radioligand binding (using either proximitymethods, such as FlashPlate, or classical filtration methods).

Products are packaged as frozen crude membrane preparations. One assay unit is defined as micrograms of protein, defined by competition binding assay (filtration). A complete product description and recommended protocol are included on the Product Information Sheet.

Some of our receptors may be restricted for sale in specified countries. Please inquire.

Specifications

Assay Target Class GPCR
Assay Target Type Membrane preparation
Assay Validated Binding
G-Alpha Natural Receptor Gq/G11
Host Cell HEK293
Product Brand Name Membrane Target Systems
Receptor Type Neurotensin
Shipping Condition Dry Ice
Therapeutic Area Central Nervous System, Pain, Inflammation
Unit Size 400 units
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Brochure

GPCRs: The Pathway to Discovery

G protein coupled-receptors (GPCRs) are one of the most intensively studied drug targets, with up to one-third of all marketed therapeutics acting by binding to GPCRs. Therapies that target GPCRs include both agonist and antagonists that are used in the treatment of disease in nearly every major organ system and hold significance in several therapeutic areas, such as cardiovascular diseases, neurosciences, respiratory diseases, metabolic disorders, oncology, and rare diseases.

We know the importance of furthering GPCR research - and we answer the call with application notes, white papers, and end-to-end solutions including reagents, instruments, and tools for all aspects of research into today’s most promising drug target.

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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed today.

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