Calcium-release activated channel CRAC / SOCE (STIM1/ORAI1)

PhotoScreen (Photina®) photoproteins are a kinetic luminescence technology for measuring calcium flux in cells. It is an alternative technology to fluorescent dyes being used on the FLIPR for studying GPCR targets. The large robust signal generated lets you screen for agonists, antagonists and allosteric modulators with reduced false positives.

We provide two vials of cryopreserved cells (approximately 2.5 x 10⁶ cells/vial) with detailed product information including cell line properties, culture conditions and the pharmacological properties of the recombinant channel in functional assays (electrophysiology - whole cell voltage clamp and calcium flux luminescence assay).

All cell lines are tested for the absence of mycoplasma.

The main therapeutic interest around CRAC originates from its role in lymphocytes and mast cells, CRAC activation being a requirement for lymphocyte activation. CRAC is currently a research target for allergic disorders, autoimmune and inflammatory diseases. As Store-Operated Calcium Entry (SOCE) is a function found in all higher eukaryotic cells there are many potential therapeutic applications for CRAC regulators.

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