ChromegaChiral™ CCO F4 is a tris(4-Fluoro 3-methylphenylcarbamate) cellulose phase which can be used in SFC or HPLC. The addition of a fluorine atom into a phenyl carbamate cellulose structure is useful in promoting a fluorophilic retention mechanism which provides improved retention for fluorinated compounds. A fluorophilic retention mechanism is particularly useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine.
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Chirality has become critically important in the pharmaceutical, chemical, and agricultural industries. The subtle differences that make compounds chiral can produce dramatically different pharmacological effects in biological systems. As a result, the demand for stereoselective separation techniques and analytical assays to evaluate the enantiomeric purity of chiral compounds, has increased. Chiral chromatography in the forms of HPLC and SFC has become a necessary tool - not only for the analytical determination of enantiomeric purity, but also for the isolation and purification of enantiomers.
As a leader in chiral separations we are able to offer you a broad range of ES Industries ChromegaChiral Chiral Stationary Phases (CSPs) for your analytical and preparative chromatography needs. Existing chiral stationary phases can separate a wide variety of chiral mixtures, however there are still enantiomeric mixtures that are difficult to separate limiting their characterization. This provides our drive to develop new CSPs with differing chiral selectivities.
|Inner Diameter||3 mm|
|Particle Size||5.0 µm|
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ChromegaChiral CCO F2 is a fluorinated phase for chiral separations and was developed in collaboration with Bill Farrell of Pfizer, La Jolla, CA. It incorporates a fluoro group in its structure. The addition of a fluorine atom into a phenyl carbamate cellulose structure can be useful in promoting ...