GrowDex® is an animal-free hydrogel that enables complete control over the culture environment for cells.
GrowDex can be used in a wide range of cell-based assays such as microscopic imaging or metabolic activity measurement. GrowDex has been validated on various cell models and applications including primary hepatocytes, patient derived cells, 3D organoid formation, hepatocyte toxicity, stem cell proliferation and differentiation, tumour cell migration and invasion, neurite outgrowth and network formation.
GrowDex is for research use only and should not be used for diagnostic or therapeutic purposes.
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GrowDex has been designed to provide a support matrix for the culture of cells in a wide range of applications. It comprises of two components, nanofibrillar cellulose (NFC) and ultra-pure water. The length of the nanofibrils ranges from 200-300 μm, with a diameter in the nanometer scale varying from 5-100 nm.
The product is supplied sterilized, ready to use and can be utilized in a variety of cell culture applications, such as 3D spheroid or organoid formation.
Storage and shelf-life:
GrowDase™ enzyme breaks down GrowDex hydrogel to form a solution in an easy one step efficient cell recovery process. 3D cell structures such as spheroids, organoid or biopsies are retained with no impact on cell viability or functionality. Liberated cells can be used in gene or protein expression studies or for future experiments.
In this application note, we establish methodologies for 3D cell culture of the common neuronal cell line SH-SY5Y within GrowDex hydrogel to provide a more biomimetic set of environmental cues with which to promote cell migration and neurite outgrowth, whilst sustaining the viability of the populati ...
Notably, mesenchymal stem cells (MSCs) are the most researched cells for their potential use in cell-based therapies. As such, it is crucial to fully characterise these cells within novel 3D environments prior to their use and application for such therapies. In this application note, adipose derived ...
"MCF7 is an adenocarcinoma cell line derived from breast tissue with metastatic and pleural effusion morphology. As it is one of the few cancer cell lines expressing estrogen receptor a (ER-a), it is the most published cell line in the field of breast cancer research. In this study, the morphology d ...
In this study pre-differentiated human pluripotent stem cell derived neurons were encapsulated within GrowDex and cultured.
In this study, we establish methodologies for 3D cell culture of human iPSC-derived neural progenitors within nanofibrillar cellulose hydrogel, GrowDex®.
GrowDex can easily be diluted with e.g. cell culture media, PBS, or ultra-pure water for use in cell-based assays. The optimal concentration will depend on the cell type being used. This application note provides a recommended procedure for the dilution and mixing of Growdex.
In this application note, we address some of the challenges of producing 3D culture models, using GrowDex® hydrogel as a 3D cell culture matrix for growing liver-derived HepG2 cells in 384-well microtiter plates.
In this study, the morphology development of MCF7 cells in GrowDex® and in Matrigel is presented.
In this application note, 3D culture of a novel NRAS mutated human melanoma cell line MUG-Mel2 in GrowDex is presented.
This document provides instructions for use, safety information, storage instructions, ordering and contact information for GrowDex.
This guide describes a number of experimental protocols performed using GrowDex hydrogels.
Download our guide to reducing the costs and time required to set up reproducible high-throughput and high-content screens using 3D cell culture models.
Animal-derived matrices for 3D cell culture are often poorly defined and suffer from lot-to-lot variability. This variability ultimately affects the reproducibility of the experiment, which is an essential element for reliable research studies.
Natural, reliable and ready-to-use, GrowDex