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Glibenclamide, Glyburide, [Cyclohexyl-2,3-3H(N)]-, 250µCi (9.25MBq)

Glibenclamide (glyburide) tritiated at the cyclohexyl-2,3 position. Glibenclamide is an antidiabetic drug that binds and inhibits the ATP-sensitive potassium channel.

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Glibenclamide acts as an antagonist at the thromboxane A2 receptor and at ATP-sensitive K+ channels.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1024:

  1. Bernardi H., Lazdunski M. (1993) Characterization of the Sulfonylurea-Sensitive ATP-Modulated Potassium Channel. In: Glossmann H., Striessnig J. (eds) Methods in Pharmacology. Springer, Boston, MA.
  2. Eiki J, Saeki K, Nagano N, Iino T, Yonemoto M, Takayenoki-Iino Y, Ito S, Nishimura T, Sato Y, Bamba Met al. 2009, A selective small molecule glucagon-like peptide-1 secretagogue acting via depolarization-coupled Ca (2+) influx. Journal of Endocrinology 201 361–367.


Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Label Position Nominally Labeled
Molecular Weight 494.0
Radioisotope H-3
Radionuclide 3H
Receptor Type Potassium
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic
Unit Size 250 µCi
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Radiometric Reagents Guide 2010-2011

For over 50 years PerkinElmer has been a leading supplier of radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments. Today is no different. We have always been committed to providing you products for all of your radiometric needs and we are still committed t ...