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Gabapentin [3H]

Tritiated gabapentin (Neurontin). Gabapentin is a medication used to treat epilepsy, and has been shown to cross membrane lipid barriers via system L-amino acid transporters and bind to voltage-gated calcium channels in the central nervous system. This product has a scheduled release for the third Monday in February and September.

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Gabapentin has been shown to bind voltage-dependent calcium channels in the central nervous system, and has been shown to attenuate pain in neuropathy. It is also used in the treatment of epilepsy.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1182:

  1. Justin V. Louis, Yifeng Lu, Rick Pieschl, Yung Tian, Yang Hong, Kumaran Dandapani, Sreenivasulu Naidu, Reeba K. Vikramadithyan, Carolyn Dzierba, Sarat Kumar Sarvasiddhi, Susheel J. Nara, Joanne Bronson, John E. Macor, Charlie Albright, Walter Kostich, Yu-Wen Li, [3H]BMT-046091 a potent and selective radioligand to determine AAK1 distribution and target engagement, In Neuropharmacology, Volume 118, 2017, Pages 167-174.


Concentration 1.0 - 10 mCi/mL
Detection Method Radiometric
Fresh Lot Days Third Monday in February and September
Label Position Specifically Labeled
Molecular Weight 171.24
Product Brand Name NEN Radiochemicals
Radioisotope H-3
Radionuclide 3H
Shipping Condition Dry Ice
Special Ordering Information This is a radioactive product - shipping address must have a license to receive radioactive materials.
Therapeutic Area CNS & Neurologic, Pain
Unit Size 1 mCi