Epic™ C4 SD is a highly base deactivated high carbon super dense (SD) phase that is produced via a multiple step process. The first step involves the high density bonding of monomeric C4 reagent. The second step utilizes a proprietary multiple endcapping bonding process that produces highly base deactivated columns. The Epic C4 SD product, as a result of our special bonding treatment, is highly hydrophobic and exceptionally inert for the analysis of both acids and bases. The unique chemical structure provides for stable retention under high aqueous conditions, without exhibiting phase collapse. Epic C4 SD is the least hydrophobic of the alkyl phases (C18 and C8) and is useful for lipophilic molecules and applications which require less retention.
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The Epic™ line our latest range of LC columns, based on high density monomerically bonded phases produced through a proprietary bonding process. Epic HPLC and UHPLC columns are compatible with a wide range of organic modifiers and buffers and stable over a wide pH range. All Epic products use an ultra-high purity metal free silica and undergo strict quality control testing. For flexibility, we offer a wide range of column sizes as well being fully scalable from analytical to preparative dimensions.
Features and Benefits:
|Inner Diameter||2.1 mm|
|Particle Size||3.0 µm|
Lamotrigine is an antiepileptic drug belonging in the phenyl triazine class. It is used in the treatment of both epilepsy and as a mood stabilizer for bipolar disorder. Lamotrigine related compound B also known as 2,3-dichlorobenzoic acid is a key intermediate for the antiepileptic drug Lamotrigine. It may be in found in the final product and needs to be monitored and controlled over the shelf life of the product.
The methods for assessing Lamotrigine related compound B are described in the United States Pharmacopeia1 and rely on chromatographic techniques. This application brief describes use of an Epic C18 column coupled with the LC 300 liquid chromatography system and SimplicityChrom chromatography data system (CDS).
Every decision you make in the lab affects your scientific outcomes – and that holds true for column choices. Sample solubility, chemical differences among analytes, and stationary phase chemistry are key factors in deciding which column is right for your application. The column vendor you choose must deliver the reliability, scalability, and reproducibility you need to get the most value from your method-development, quality-control, and preparative-purification processes.
Our innovative, highly efficient HPLC/UHPLC and supercritical fluid chromatography (SFC) column chemistries from ES Industries (now a PerkinElmer company) provide scientists like you with the highest quality columns, including novel chiral and achiral fluorinated phases specifically designed with pharmaceutical and environmental applications in mind. Building on ES Industries’ 40 years’ experience in column technology, we support you with applications assistance, method development guidance, and column recommendations, too.