The EnVision® 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.
The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP).
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For research use only. Not for use in diagnostic procedures.
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Our gold-standard for high-throughput screening, the EnVision provides exceptional sensitivity and speed with minimal downtime – backed by our global network of application scientists and engineers.
Our Alpha and LANCE® reagents are developed and optimized on the EnVision plate reader so you can be confident of accurate results. Plus, we can cite over 15,000 published papers that attest to its real-world performance across a broad range of applications.
Two configurations are available, which both offer the same unsurpassed sensitivity and analytical performance
We understand your science and applications. Combine many years’ experience developing and supporting multimode plate readers and reagents with a global network of application scientists and engineers, and you can be confident of minimal downtime.
You can also access our Application Support Knowledge base (ASK) which provides a comprehensive set of technology-specific and application-specific scientific articles, written by our R&D, technical support, and applications teams, enabling you to access scientific support 24 hours a day/7 days a week.
EnVision is part of our complete solution for screening. For high-throughput screening, we offer assays and reagents, radioimmunoassays and radiometric detection, microplates and automation, in addition to multimode plate readers. We also offer solutions for phenotypic screening such as high-content screening systems and for data analysis such as Signals™ for Screening.
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|21 CFR Part 11 Compatible||Yes|
|Detection Method||Absorbance, Time-Resolved Fluorescence (TRF), Luminescence, Alpha, Fluorescence, Fluorescence Polarization|
|Product Brand Name||EnVision|
A monochromator is an optical device known for its ability to separate the colors of light,using an element called diffraction grating. By changing the angle of this grating the,light exiting the monochromator through a fixed slit will be of a desired wavelength.,This easy way of acquiring and selecting pure – or monochromatic – light makes it a,suitable technology for microplate readers. Not only does it free users to experiment,with assays regardless of their set of filters available, but it also facilitates some new,application areas traditionally not associated with plate readers e.g. spectral scanning.
In this application note, we demonstrate an efficient cell-based workflow for the assessment of EGF treatment effects in a cellular model of human skin cancer.
Treatment effects on several intracellular signaling pathways were examined using PerkinElmer’s homogeneous, no-wash AlphaLISA® SureFire® Ultra assays. To determine concurrent time-dependent effects of different EGF concentrations on cellular health and proliferation, ATP concentrations were assessed with ATPlite™ 1step luminescence assay and cultures were fluorescently labeled, imaged and analyzed using the Operetta CLS™ high-content analysis system.
Cellular kinase signal transduction pathways are involved in the regulation of many important cellular processes such as cell survival, differentiation, and apoptosis. Kinase signaling networks are typically characterized by multiple kinases arranged in cascades containing nodes with feedback loops and crosstalk between pathways. Numerous assay technologies have been developed for studying kinase signaling pathways, and for screening compound libraries in search of agents to modify receptors or kinase activities. The quality of these assays can be impacted by data variability due to cell seeding inhomogeneity or from compound toxicity. A common method for controlling for variability is to normalize the assay signal to a cellular protein whose level does not change as a function of the treatment.
Alpha SureFire® Ultra™ Multiplex Phospho and Total assays utilize two types of Alpha Acceptor beads to simultaneously measure two signals from each assay well to easily normalize the assay. Here, we demonstrate the benefit and utility of normalizing assay signal of phosphorylated protein levels to total protein levels in two different cellular models: ERK 1/2 phosphorylation in human melanoma A375 cells and AKT 1/2/3 phosphorylation in mouse myoblast C2C12 cells.
Publication note on a-Fetoprotein Assay on Dried Blood Spot for Hepatoblastoma Screening using VICTOR and EnVision plate readers and DELFIA
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automated liquid handling, assays and reagents, imaging and detection systems, and informatics.
Working independently or together, with our solutions you can achieve consistent and accurate results. By accelerating the identification and characterization of effective and safe drug candidates, the PerkinElmer portfolio enables you to optimize efficiency in your lab and deliver more actionable, real-world results.
Download the brochure to learn more about how we can partner with you so that you can discover smarter, more effective, data-driven breakthroughs in the critical screening stages of drug discovery and development.
Selecting the right plate reader for your lab can be challenging. There are multiple factors to consider including: detection type, additional features, support, and price. With numerous options for each variable, it can be confusing to navigate the selection process. Focusing on striking a balance between functionality, optimization, and growth potential requires keen insight and continued vendor support throughout the life cycle of the plate reader.
This detailed guide will help you choose the right plate reader for your needs by examining the marketplace and pointing out considerations to keep in mind when making your decision.
Reaching compliance according to the laws and regulations of each country can be a tedious, complicated process, and being GxP compliant (FDA 21 CFR Part 11, EU Annex 11, etc.) is necessary in order to deliver therapeutic treatments to market for pharmaceutical and biotechnology companies, including clinical research organizations.
Simplify compliance for your VICTOR® Nivo™, EnSight®, or EnVision® multimode plate reader with the help of our Enhanced Security software. In addition, our wide range of assays can help you achieve your research goals, and our qualification services will make sure your multimode plate reader and software are operating at the recommended technical specifications.
To guide you through the complexity of the compliance process, we can help with our proven solutions, customer training, and technical support so you can focus on your science and research.
Enzyme-linked Immunosorbent Assay is the most widely Kits adopted method for detection and quantification of cytokines and other biomarkers. This traditional technology offers good,selectivity, sensitivity and assay versatility; however, it has certain disadvantages such as limited dynamic range and low throughput due to the numerous wash steps.
Poster on High Sensitivity cAMP Assays in Primary Cells and Mesenchymal Stem Cells with the LANCE® Ultra cAMP kit