384-well microplate for use in time-resolved fluorescence, luminescence, Alpha, and radiometric assays. This white, polystyrene CulturPlate™ is sterile and tissue-culture (TC) treated for cell-based assays.
Tissue-culture treated microplates are supplied with lids except when supplied in a case of 200 microplates. Lids for a case of 200 microplates must be purchased separately. Please see part number 6005619, sterile, universal lids for 96-well plates.
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The CulturPlate is PerkinElmer's microplate designed for cellular assays, tissue-culture treated and sterilized by gamma-irradiation to facilitate adherent cell growth. The optimized well design and high quality plastics provides low background and crosstalk.
CulturPlates are uniquely engineered to be the same height for 96-, 384-, and 1536-well plates, and with extraordinary well flatness for ease in automation.
Leveraging years of assay and instrument experience in plate detection, PerkinElmer designs better Microplates for better performance that guarantees better results for all PerkinElmer applications.
|Coating Treatment||TC-treated, Sterile|
|Detection Method||Luminescence, Alpha, Time-Resolved Fluorescence (TRF & TR-FRET), Radiometric|
|Product Brand Name||CulturPlate|
|Unit Size||Case of 50|
|Wells Number||384 well plate|
Immuno-oncology is an exciting area within cancer research and among the most promising approaches to activating therapeutic antitumor immunity is through the blockade of immune checkpoints. The programmed cell death-1 (PD-1) immune checkpoint pathway is a negative regulator of T cell immune function. When PD-1 is bound to programmed cell death-ligand 1 (PD-L1), T cell response is suppressed. Many tumor cells escape anti-tumor immunity through their expression of Programmed Death Ligand 1 (PD-L1 or B7-H1), which interacts with T cell-expressed PD-1 and results in T cell apoptosis. PD-L1 expression has been studied in multiple different cancers. While several anti-PD-1 or PD-L1 monoclonal antibodies that block the PD-1/ PD-L1 complex formation have been developed to date, there remains a need for more robust, rapid, high-throughput assays to identify and qualify novel inhibitors of PD-1/PD-L1 binding and assays to detect expression levels of both binding partners. Find out how LANCE® Ultra Technology provides a fast, powerful, homogeneous platform for identifying and characterizing endogenous PD-L1 and PD-1 expression in human cells.
Poster on High Sensitivity cAMP Assays in Primary Cells and Mesenchymal Stem Cells with the LANCE® Ultra cAMP kit