ChromegaChiral™ CCO F2 is a tris(2-Fluoro 5-methylphenylcarbamate) cellulose phase which can be used in SFC or HPLC. The addition of a fluorine atom into a phenyl carbamate cellulose structure can be useful in promoting a fluorophilic retention mechanism which can provide improved retention for fluorinated compounds. A fluorophilic retention mechanism can be particularly useful in medicinal chemistry and drug discovery, where more than a third of newly approved small molecule drugs contain fluorine.
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Chirality has become critically important in the pharmaceutical, chemical, and agricultural industries. The subtle differences that make compounds chiral can produce dramatically different pharmacological effects in biological systems. As a result, the demand for stereoselective separation techniques and analytical assays to evaluate the enantiomeric purity of chiral compounds, has increased. Chiral chromatography in the forms of HPLC and SFC has become a necessary tool - not only for the analytical determination of enantiomeric purity, but also for the isolation and purification of enantiomers.
As a leader in chiral separations we are able to offer you a broad range of ES Industries ChromegaChiral Chiral Stationary Phases (CSPs) for your analytical and preparative chromatography needs. Existing chiral stationary phases can separate a wide variety of chiral mixtures, however there are still enantiomeric mixtures that are difficult to separate limiting their characterization. This provides our drive to develop new CSPs with differing chiral selectivities.
|Inner Diameter||4.6 mm|
|Particle Size||3.0 µm|
Today's advanced and increasingly diverse laboratories are facing new challenges on a daily basis – starting from raw materials right up to the finished product. Our comprehensive portfolio of analytical solutions is designed to give you the higher accuracy, sensitivity, and ease of use your laboratory demands for examining with confidence, the purity, composition, and performance of your compounds. What’s more, a range of complementary services is available to keep your laboratory up and running, meeting the stringent requirements of a variety of environments and working practices. Better insights for better products. View our full Chromatography portfolio here.
ES Industries is now part of PerkinElmer, bringing customers new opportunities for full performance-boosting LC workflow solutions.
ES Industries is known for its innovative and highly efficient HPLC and supercritical fluid chromatography (SFC) column chemistries. The team has over 40 years of experience delivering columns with superior reliability, scalability, and reproducibility that are used routinely for method development processes, LC/MS analysis, quality control and preparative purification. They were the first to commercialize “AQ” chemistry (L1); now widely adopted in LC and LC/MS, and first to commercialize the PFP phase (L43); now common-place in method development. The portfolio includes novel chiral and achiral fluorinated phases for pharma and environmental applications. Download the full catalog to view our full LC column workflows and offerings.