PerkinElmer
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Cat K 680 FAST Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.  

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For laboratory use only. This product is intended for animal research only and not for use in humans.

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Detail Information

Cat K 680 FAST™ is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology), that confers an improved pharmacokinetic profile with earlier imaging time points. This architecture offers higher target specific signal with reduced background while also reducing the optimal imaging time after injection. 

Cat K 680 FAST is a Cathepsin K (Cat K) activatable fluorescent agent that is optically silent upon injection and produces fluorescent signal after cleavage by disease related Cathepsin K. Cat K is highly expressed in osteoclasts, suggesting a specialized role in bone resorption. 

Cat K is found extracellularly along the bone and cartilage and intracellularly in lysozomes of osteoclasts attached to the bone. In addition to expression by osteoclasts, Cat K is also expressed by a broad range of other cell types including ovarian cells, colonic tissue, alveolar and bronchial epithelial cells, synovial fibroblasts, breast cancer cells, macrophages.

Specifications

Fluorescent Agent Type Activatable
Optical Imaging Classification Fluorescence Imaging
Product Brand Name Cat K FAST
Quantity in a Package Amount 1.0 Units
Shipping Condition Ambient
Therapeutic Area Atherosclerosis, Arthritis
Unit Size 1 Vial (10 doses)
Wave Length 680 nm
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Application Note

In Vivo Imaging of Atherosclerosis Disease Using FMT

Current means of measuring disease in preclinical models of atherosclerosis include ex vivo assessment of disease tissues post-mortem and non-invasive imaging primarily of structural and anatomic features of lesions, in vivo. A non-invasive, quantitative means of imaging known biologic profiles associated with atherosclerotic disease, in vivo, would enable a robust additional understanding and analysis of disease progression and therapeutic response in research and drug development. We report the utility of the near infrared (NIR) protease-sensing, ProSense® 750 Fluorescent Pre-clinical Imaging Agent, in combination with the FMT® 2500 Quantitative Pre-clinical Imaging System for the non-invasive quantitative measurement of atherosclerotic disease biology and related response to therapy in apolipoprotein (apo) E-deficient mice in vivo. FMT (Fluorescence Molecular Tomography) imaging measured significant increases in aortic region protease activity with a range of values that were comparable to the range seen in the ex vivo aortic arches assessed by fluorescence reflectance imaging (FRI).

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Poster

Development of a Fast Activating New Near Infrared-Labeled Agent for Detecting

Cat K 680 FAST is a cathepsin K activatable agent that is optically silent upon injection and produces fluorescent signal after being cleaved by disease-related cathepsin K. Cathepsin K is highly expressed in osteoclasts, suggesting a specialized role in bone resorption, and also in synovial fibroblasts.

PDF 672 KB
Imaging of Cathepsin K activity in rodent models of bone turnover and soft tissue calcification

Imaging of Cathepsin K activity in rodent models of bone turnover and soft tissue calcification

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Technical Note

Cat K 680 FAST (Data Sheet)

Cat K™ 680 FAST is a member of a family of activatable fluorescent imaging agents comprising a novel architecture, termed F.A.S.T. (Fluorescent Activatable Sensor Technology), that confers an improved pharmacokinetic profile with earlier imaging time points. This architecture offers higher target specific signal with reduced background while also reducing the optimal imaging time after injection. Cat K 680 FAST is a Cathepsin K (Cat K) activatable agent that is optically silent upon injection and produces fluorescent signal after cleavage by disease related Cathepsin K. Cat K is highly expressed in osteoclasts, suggesting a specialized role in bone resorption. Cat K is found extracellularly along the bone and cartilage and intracellularly in lysozomes of osteoclasts attached to the bone. In addition to expression by osteoclasts, Cat K is also expressed by a broad range of other cell types including ovarian cells, colonic tissue, alveolar and bronchial epithelial cells, synovial fibroblasts, breast cancer cells, macrophages.

PDF 153 KB
Cat K 680 FAST (Protocol)

Cat K 680 FAST activatable fluorescent imaging agent protocol

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