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The AxION® 2 TOF MS offers a broad array of capabilities designed to simplify and streamline virtually any analytical workflow and provides mass accuracy, full spectrum capability, speed, sensitivity, or dynamic range.

Part Number MZ320025
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For research use only. Not for use in diagnostic procedures.


PerkinElmer offers a variety of innovative hardware and software solutions to complement the AxION 2 TOF MS specifically designed to streamline and simplify today’s laboratory workflows. Simply select the package best suited to your specific application and you’ll discover an intuitive, robust interface offering everything you need to convert complex samples into confident results.

  • Multi-source compatibility - Easily fitted with patented field-free APCI, ESI, and DSA systems for the most flexibility
  • Snap in, snap out probes - decrease cross contamination and enhance productivity with minimal down time
  • TrapPulse technology-patented design feature that increases sensitivity 8X.
  • Linear dynamic range -confidently quantitate with exact mass
  • Precise isotope ratio measurements and accurate mass - for confident identification of both unknown and known compounds
  • Automated tuning - ensures your instrument is optimized for your application
  • Capillary shutter - change the capillary without venting the instrument decreasing downtime
  • Software solutions - streamline your workflow and increase productivity with AxION platform software solutions


21 CFR Part 11 Compatible Yes
Maximum Temperature 26 °C
Minimum Temperature 16 °C
Portable No
Product Brand Name AxION
Technology Type Mass Spectrometry
Warranty 1 year
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Application Note

A Quantitative SLE LC TOF MS Method to Detect Multiple Drugs in Urine

Liquid chromatography-mass spectrometry (LC/MS) is commonly used to measure drugs and their concentrations in extracts of biological matrices. Triple quadrupole MS is often employed for targeted quantitative analysis, using multiple reaction monitoring (MRM) mode. Here, the intensity of product ions ...

Analysis of Cathinones in Bath Salts by Direct Sample Analysis TOF MS

There is no standard method to quickly screen and confirm cathinones in bath salts. To address this issue, use of the AxION® Direct Sample Analysis™ (DSA™) integrated with the AxION 2 time-of-flight,mass spectrometer (TOF) (PerkinElmer, Waltham, MA) was implemented. Cathinone standards and bath salt ...

Analysis of Pharmaceutical and Personal Care Products in River Water Samples by UHPLC-TOF

We present a study of PPCPs in river water samples from the northeastern United States using UHPLC-TOF-MS for both targeted and non-targeted analytes. Unlike a triple quadrupole, which is operated in multiple reaction monitoring mode for screening only predefined targeted analytes, the time-of-fligh ...

PDF 951 KB
Analysis of Quaternary Ammonium Compounds (QACs) as Possible Disinfectant Residues in Milk by LC-TOF

Quaternary ammonium compounds (QACs) have the basic structure NR4. Those possessing R groups with long alkyl chains are known to be especially effective as antimicrobial agents and particularly useful for the disinfection of containers and surfaces.

Automated Direct Sample Analysis (DSA/TOF) for the Rapid Screening and Confirmation of Illicit Street Drugs

Screening methods for drugs of abuse,currently require long chromatographic,methods and sample preparation or,immunoassay techniques (EMIT) with,confirmation by GC/MS or LC/MS/MS.

Differentiation of Cultivars of Spanish Olive Oils Using Multiple LC/MS Analysis Methods

The patterns of organic components in olive oils relate to the geographic origin, cultivar and processing methods for the olives. In this study a statistical analysis of the chemical components of authentic monovariatal virgin olive oils from Spain was used to determine markers for the cultivars. Th ...

PDF 348 KB
Differentiation of Olive Varieties by the Triacylglyceride Levels of Oils –Statistical Analysis of LC/MS Results

Olives of different cultivars are used to produce oils with different particular flavors and stability. Oils of known cultivars from designated areas may be certified for authenticity, and are marketed internationally, commanding a price premium. This study reports on the measurement of the triacylg ...

Differentiation of Olive, Vegetable and Seed Oils by LC/MS Analysis of Triacylglycerides

Extra virgin olive oil has been adulterated throughout history with less expensive oils such as soybean or hazelnut oil. Detecting adulteration is important for maintaining both the safety and consumer confidence of this product. This study reports on the measurement of the triacylglyceride composit ...

Food Packaging Compendium

Need to ensure quality, safety and reliability of food packaging? This compendium of Application Notes will provide you with R&D and QA/QC insights from plastic food trays, to bags, films and canned goods. The compendium provides research data and experimental results for; mechanical durability ...

Identification of Microcystins as Markers of Algal Bloom Contamination in Surface Waters

Contamination of surfacewaters by algal blooms hasemerged as a public healthissue. Among the types ofalgae that can form algalblooms, photosynthetic cyanobacteria (also known as blue-green algae) can be particularlytoxic, and the level of toxicity can change very quickly. Issues with taste and od ...

Identification of Unanticipated Prescription Drugs and Metabolites in Donor Urine Using Accurate Mass LC/MS

LC/MS analysis showed that a number of non-endogenous compounds were detected in this urine.

PDF 571 KB
LC/TOF MS Analysis of Phosphodiesterase Type 5 Inhibitors Extracted from Herbal Preparations

Dietary supplement use is becoming more prevalent among adults. With this increased use there has been a concomitant rise in dietary supplement adulteration.

PDF 740 KB
Markers for Spanish Olive Oil Cultivars – Statistical Analysis of Polar Compounds from LC/MS Results

Polar components such as phenolic acids and lignans are present in olive oils. Secoiridoids; phenolics which include an elenolic acid moiety, are unique to the Olearaceae family. These compounds are known to have beneficial health effects due to their antioxidant properties and are associated with t ...

PDF 697 KB
Meeting EU REACH Requirements using Chemical Ionization Gas Chromatography/ Mass Spectrometry

The EU Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) regulation was adopted in 2006 with the aim of protecting human and environmental health, along with the competitiveness of the chemical industry within the European Economic Area. The regulation places responsibi ...

Milk Adulteration with Melamine - Screening, Testing and Real-Time Detection

This work highlights that screening, testing or real-time detection can be utilized to detect melamine-adulterated milk in a supply chain and that by determining where the sampling is taking place, who is carrying out the measurement and whether the testing is to meet regulation, will define which t ...

Quantification of Benzodiazepines in Plasma Using UHPLC Time-of-flight Mass Spectrometry

Presented is an alternative technique to quantitate benzodiazepines in plasma using a rapid protein precipitation method with a fast LC separation method in combination with TOF-MS.

Quantitative Analysis of Analytes in Urine using UHPLC Coupled to Accurate Mass AxION 2 TOF Mass Spectrometer

The PerkinElmer AxION® Time of Flight (TOF), fitted with ADC detector technology, provides a wide dynamic range and is suitable for quantitative analysis of target along with qualitative screening of unknown compounds. In this application note we present a workflow for the testing and quantification ...

Rapid Analysis of Apple Juice Adulteration with Pear Juice Using LC/TOF

Adulteration of fruit juices is quite common in the market place and is often done through juice substitution. Pear juice has a slightly lower market value than apple juice yet both have similarities in major chemical composition, making pear juice an ideal adulterant for apple juice. Both juices ha ...

Rapid Detection of Vanilla Bean Extract Adulteration with Tonka Bean Extract with No Chromatography or Sample Preparation

A variety of analytical techniques such as GC/MS, LC/MS, LC/UV, headspace GC/MS and stable isotope ratio analysis have been used to characterize vanilla bean extracts and detect its adulteration3-6. These measurement techniques are either expensive, time consuming, or both, and require extensive met ...

Rapid Measurement of Olive Adulteration with Seed Oil

Olive oil and other oils are composed mainly of triacylglycerols. These molecules are derived from the esterification of three fatty acid molecules with a glycerol molecule. The main triglyceride in olive oil is triolein (OOO); whereas the main triglyceride in seed oils (soybean, corn and sunflower) ...

Rapid Screening of Adulteration in Pomegranate Juice with Apple Juice Using DSA/TOF with Minimal Sample Preparation

Pomegranate juice is in high demand due to its well documented health benefits. Studies based on a significant body of scientific research conducted on authentic pomegranate juice have,established that pomegranate juice has superior antioxidant activity compared to other popular fruit juices such as ...


This reference notebook offers a diverse mix of forensic applications that specifically highlight the unique performance characteristics of the AxION 2 TOF and AxION DSA. Learn how our techniques and technology can screen, confirm and quantify various known and unknown sample types across a wide ran ...

Testing and Quantification of Opioids in Serum by UHPLC-TOF

Testing of opioids is most commonly done using the Enzyme Multiple immunoassay Test (EMIT). Immunoassays suffer from non-specificity as they can only identify a class of drugs and cannot identify the specific compound within the class. As an example an immunoassay SAMHSA panel screens for opiates su ...

Testing and Quantification of Opioids in Urine by UHPLC-TOF

We present a study for screening of opioids along with the quantitation of the drugs in urine using a time-of-flight (TOF) mass spectrometer (MS) for use in forensic laboratories.

Whisky Origins Profiled By Data Fusion of LC/MS and ICP-MS Results Using TIBCO Spotfire Software

This study used TIBCO Spotfire® statistical analysis to investigate whether whisky compound profiles are specific to regional origins. Malt whiskies contain a large number of compounds, which vary according to the local ingredients, fermentation, distillation and maturation processes.

Workflow for Quantification of Benzodiazepines in Urine Using UHPLC- TOF

We present an alternative technique to quantitate benzodiazepines in urine utilizing a rapid dilute and shoot LC method in combination with time-of-flight mass spectrometry (TOF MS).



AxION 2 TOF Brochure

The AxION 2 TOF MS offers a broad array of capabilities designed to simplify and streamline virtually any analytical workflow. Whether your application places an emphasis on the instrument’s mass accuracy, full spectrum capability, speed, sensitivity,dynamic range, or all of the above, the AxION 2 T ...

AxION Solo/Xpo Call Out Sheet

Designed for optimal flexibility and productivity, AxION® Solo™ streamlines the most complex LC/MS analyses by allowing you to define your own criteria and processing methods to find one or many substances by mass or formula. An intensity-driven heat mapping and graphical user interface provides sup ...

PDF 295 KB


AxION eDoor SQ Flyer

From running an individual sample to managing a complete network of instruments and users, AxION® eDoor™ has the power to simplify every aspect of your laboratory operation. A robust yet intuitive open-access software, eDoor works with the Flexar™ SQ 300 MS to deliver reliable, high quality MS resul ...

PDF 642 KB


Analysis of Impurities in Melatonin by LC/TOF-MS

Melatonin is a hormone secreted by the brain to help regulate sleep. Since melatonin is found in certain foods, it can be sold as a dietary “over-the-counter” (OTC) supplement.

PDF 270 KB
Confirmation of drugs of abuse in pseudo drug mixes using UHPLC-ESI TOF MS

Forensic crime labs are responsible for the qualitative confirmation of drugs of abuse for use in court cases. Gas chromatography mass spectrometry (GCMS) has been the gold standard for confirmation of cocaine, procaine, and morphine in confiscated illicit drugs.

PDF 224 KB

Technical Note


AxION 2 TOF MS Product Note

AxION 2 TOF TrapPulse TechNote

Designed for optimal flexibility and productivity, AxION® Solo™ streamlines the most complex LC/MS analyses by allowing you to define your own criteria and processing methods to find one or many substances by mass or formula. An intensity-driven heat mapping and graphical user interface provides sup ...

PDF 228 KB