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The AxION® 2 TOF MS offers a broad array of capabilities designed to simplify and streamline virtually any analytical workflow and provides mass accuracy, full spectrum capability, speed, sensitivity, or dynamic range.

Part Number MZ320025
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For research use only. Not for use in diagnostic procedures.


PerkinElmer offers a variety of innovative hardware and software solutions to complement the AxION 2 TOF MS specifically designed to streamline and simplify today’s laboratory workflows. Simply select the package best suited to your specific application and you’ll discover an intuitive, robust interface offering everything you need to convert complex samples into confident results.

  • Multi-source compatibility - Easily fitted with patented field-free APCI, ESI, and DSA systems for the most flexibility
  • Snap in, snap out probes - decrease cross contamination and enhance productivity with minimal down time
  • TrapPulse technology-patented design feature that increases sensitivity 8X.
  • Linear dynamic range -confidently quantitate with exact mass
  • Precise isotope ratio measurements and accurate mass - for confident identification of both unknown and known compounds
  • Automated tuning - ensures your instrument is optimized for your application
  • Capillary shutter - change the capillary without venting the instrument decreasing downtime
  • Software solutions - streamline your workflow and increase productivity with AxION platform software solutions


21 CFR Part 11 Compatible Yes
Maximum Temperature 26 °C
Minimum Temperature 16 °C
Portable No
Product Brand Name AxION
Technology Type Mass Spectrometry
Warranty 1 year
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Application Note

A Quantitative SLE LC TOF MS Method to Detect Multiple Drugs in Urine

Liquid chromatography-mass spectrometry (LC/MS) is commonly used to measure drugs and their concentrations in extracts of biological matrices. Triple quadrupole MS is often employed for targeted quantitative analysis, using multiple reaction monitoring (MRM) mode. Here, the intensity of product ions resulting from the collisionally induced fragmentation of a specified precursor ion is measured. Using MRM mode requires complex method optimization for each compound and the measurement is limited to targeted species. In contrast, time-of-flight (TOF) MS has higher mass resolution than quadrupole MS and allows for post-acquisition data interrogation of drugs and metabolites not originally specified in the experimental method. This latter process is not possible using triple quadrupole MRM data, which only records information on those species originally specified. This study was conducted to evaluate the performance of a quantitative LC/TOF MS method to detect 52 drugs and drug metabolites in human urine.

Analysis of Cathinones in Bath Salts by Direct Sample Analysis TOF MS

There is no standard method to quickly screen and confirm cathinones in bath salts. To address this issue, use of the AxION® Direct Sample Analysis™ (DSA™) integrated with the AxION 2 time-of-flight,mass spectrometer (TOF) (PerkinElmer, Waltham, MA) was implemented. Cathinone standards and bath salt samples were rapidly screened and confirmed in seconds by accurate mass and isotopic distribution of parent and fragment ions using DSA/TOF and AxION Solo™ software.

Analysis of Pharmaceutical and Personal Care Products in River Water Samples by UHPLC-TOF

We present a study of PPCPs in river water samples from the northeastern United States using UHPLC-TOF-MS for both targeted and non-targeted analytes. Unlike a triple quadrupole, which is operated in multiple reaction monitoring mode for screening only predefined targeted analytes, the time-of-flight (TOF) mass,spectrometer provides full spectrum accurate mass data that can be used to analyze and identify an unlimited number of compounds, without prior knowledge of target analytes or when reference standards are not available. In this study we show how high mass accuracy information provided by the PerkinElmer,AxION 2® TOF along with the priopriatory AxION EC ID software can be used to identify unknown analytes in surface river waters.

PDF 951 KB
Analysis of Quaternary Ammonium Compounds (QACs) as Possible Disinfectant Residues in Milk by LC-TOF

Quaternary ammonium compounds (QACs) have the basic structure NR4. Those possessing R groups with long alkyl chains are known to be especially effective as antimicrobial agents and particularly useful for the disinfection of containers and surfaces.

Automated Direct Sample Analysis (DSA/TOF) for the Rapid Screening and Confirmation of Illicit Street Drugs

Screening methods for drugs of abuse,currently require long chromatographic,methods and sample preparation or,immunoassay techniques (EMIT) with,confirmation by GC/MS or LC/MS/MS.

Differentiation of Cultivars of Spanish Olive Oils Using Multiple LC/MS Analysis Methods

The patterns of organic components in olive oils relate to the geographic origin, cultivar and processing methods for the olives. In this study a statistical analysis of the chemical components of authentic monovariatal virgin olive oils from Spain was used to determine markers for the cultivars. These markers could be used to confirm the provenance and origins of olive oil samples. Different LC/MS methods were used to measure the levels of a large number of polar and non-polar organic components in the oils. Results from the separate analyses were combined with data fusion. A statistical comparison with the combined results improved the discrimination of cultivar groups, when compared to a single LC/MS analytical method.

PDF 348 KB
Differentiation of Olive Varieties by the Triacylglyceride Levels of Oils –Statistical Analysis of LC/MS Results

Olives of different cultivars are used to produce oils with different particular flavors and stability. Oils of known cultivars from designated areas may be certified for authenticity, and are marketed internationally, commanding a price premium. This study reports on the measurement of the triacylglyceride composition of a large number of olive oils from known origins using a simple LC/MS method, together with statistical analysis of the results to find indicators for different cultivars. Such marker compounds could be used to test the authenticity of an unknown sample.

Differentiation of Olive, Vegetable and Seed Oils by LC/MS Analysis of Triacylglycerides

Extra virgin olive oil has been adulterated throughout history with less expensive oils such as soybean or hazelnut oil. Detecting adulteration is important for maintaining both the safety and consumer confidence of this product. This study reports on the measurement of the triacylglyceride composition of a large number of olive oils and other seed and vegetable oils using a simple LC/MS method, together with statistical analysis of the results to find indicators for different oil types.

Food Packaging Compendium

Need to ensure quality, safety and reliability of food packaging? This compendium of Application Notes will provide you with R&D and QA/QC insights from plastic food trays, to bags, films and canned goods. The compendium provides research data and experimental results for; mechanical durability testing, analyzing multi-layer flexible laminates, studying extractables and leachables such as epoxyphenal-based coating, and other volatile organic compounds.

Identification of Microcystins as Markers of Algal Bloom Contamination in Surface Waters

Contamination of surfacewaters by algal blooms hasemerged as a public healthissue. Among the types ofalgae that can form algalblooms, photosynthetic cyanobacteria (also known as blue-green algae) can be particularlytoxic, and the level of toxicity can change very quickly. Issues with taste and odor withpotable water can also occur.

The dynamic status of blooms and their concomitant public health issues imply that theirmonitoring requires analytical methodologies to determine levels of chemical markers3.This application note describes the use of ultra-high performance liquid chromatography(UHPLC) coupled to Time-Of-Flight mass spectrometry (TOF/MS) to monitor the chemicalmarkers of these particular algal blooms, known as microcystins. TOF/MS is well-suited tothis task, because of its ability to perform targeted and non-targeted analysis in the sameexperiment, which allows measurement of expected contaminant compounds, and thedetection of previously unsuspected relevant chemical species.

Identification of Unanticipated Prescription Drugs and Metabolites in Donor Urine Using Accurate Mass LC/MS

LC/MS analysis showed that a number of non-endogenous compounds were detected in this urine.

PDF 571 KB
LC/TOF MS Analysis of Phosphodiesterase Type 5 Inhibitors Extracted from Herbal Preparations

Dietary supplement use is becoming more prevalent among adults. With this increased use there has been a concomitant rise in dietary supplement adulteration.

PDF 740 KB
Markers for Spanish Olive Oil Cultivars – Statistical Analysis of Polar Compounds from LC/MS Results

Polar components such as phenolic acids and lignans are present in olive oils. Secoiridoids; phenolics which include an elenolic acid moiety, are unique to the Olearaceae family. These compounds are known to have beneficial health effects due to their antioxidant properties and are associated with the organoleptic properties. Measuring the levels of these polar components in oils from different cultivars and geographic origins is of interest for nutritional and authenticity reasons. In this study a statistical analysis of the polar chemical components of olive oils was used to determine potential markers for olive cultivars. These markers could be used to confirm the provenance of unknown samples.

PDF 697 KB
Meeting EU REACH Requirements using Chemical Ionization Gas Chromatography/ Mass Spectrometry

The EU Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) regulation was adopted in 2006 with the aim of protecting human and environmental health, along with the competitiveness of the chemical industry within the European Economic Area. The regulation places responsibility for chemical product evaluation and compliance on manufactures and importers, as opposed to the government.

In this application note, a method utilizing a PerkinElmer Clarus® GC/MS for the analysis of 4,4’-Methylenebis(2,6-di-tert-butylphenol), also known as Ethyl 702, is described. The method fulfills the REACH requirement by using the ammonia adduct ion to confirm the compound molecular weight. Improved analytical results were obtained using a mass flow control (MFC) mechanism for the regulation of the CI reagent gas flow.

Milk Adulteration with Melamine - Screening, Testing and Real-Time Detection

This work highlights that screening, testing or real-time detection can be utilized to detect melamine-adulterated milk in a supply chain and that by determining where the sampling is taking place, who is carrying out the measurement and whether the testing is to meet regulation, will define which technology to use.

Quantification of Benzodiazepines in Plasma Using UHPLC Time-of-flight Mass Spectrometry

Presented is an alternative technique to quantitate benzodiazepines in plasma using a rapid protein precipitation method with a fast LC separation method in combination with TOF-MS.

Quantitative Analysis of Analytes in Urine using UHPLC Coupled to Accurate Mass AxION 2 TOF Mass Spectrometer

The PerkinElmer AxION® Time of Flight (TOF), fitted with ADC detector technology, provides a wide dynamic range and is suitable for quantitative analysis of target along with qualitative screening of unknown compounds. In this application note we present a workflow for the testing and quantification of compounds in urine. The accurate mass and isotope ratios provided by the AxION 2 TOF MS along with retention time matching is used to identify and confirm the presence of both known and unknown target analytes without the need for fragmentation information.

Rapid Analysis of Apple Juice Adulteration with Pear Juice Using LC/TOF

Adulteration of fruit juices is quite common in the market place and is often done through juice substitution. Pear juice has a slightly lower market value than apple juice yet both have similarities in major chemical composition, making pear juice an ideal adulterant for apple juice. Both juices have similar carbohydrate, organic acid and amino acid levels, therefore the detection of apple juice adulteration with pear juice, based on these compounds, has limited applicability.

Rapid Detection of Vanilla Bean Extract Adulteration with Tonka Bean Extract with No Chromatography or Sample Preparation

A variety of analytical techniques such as GC/MS, LC/MS, LC/UV, headspace GC/MS and stable isotope ratio analysis have been used to characterize vanilla bean extracts and detect its adulteration3-6. These measurement techniques are either expensive, time consuming, or both, and require extensive method development and sample preparation. In this work, we demonstrated that the AxION® Direct Sample Analysis™ (DSA™) system integrated with the AxION® 2 Time-of-Flight (TOF) mass spectrometer (DSA/TOF) can be used to detect contamination of vanilla bean extracts with tonka bean extracts with no chromatography or sample preparation, and within a few seconds.,

Rapid Measurement of Olive Adulteration with Seed Oil

Olive oil and other oils are composed mainly of triacylglycerols. These molecules are derived from the esterification of three fatty acid molecules with a glycerol molecule. The main triglyceride in olive oil is triolein (OOO); whereas the main triglyceride in seed oils (soybean, corn and sunflower) is trilinolein (LLL). Therefore, the measurement of ratio of trilinolein to triolein in olive oil can be used as a way to detect its adulteration with soybean and other seed oils, such as corn and sunflower, which have a higher content of trilinolein and lower amount of triolein in comparison to olive oil3. Using this strategy with a Direct Sample Analysis™ Time-of-Flight mass spectrometry system (DSA/TOF), we detected adulteration of olive oil with soybean and corn oil. In the past, methods employing gas chromatography/mass spectrometry (GC/MS) and high performance liquid chromatography (HPLC) hyphenated to MS (HPLC/MS) were implemented for this purpose.,

Rapid Screening of Adulteration in Pomegranate Juice with Apple Juice Using DSA/TOF with Minimal Sample Preparation

Pomegranate juice is in high demand due to its well documented health benefits. Studies based on a significant body of scientific research conducted on authentic pomegranate juice have,established that pomegranate juice has superior antioxidant activity compared to other popular fruit juices such as grape, orange and apple1,2,3. These superior health benefits have led to a meteoric rise in the popularity of pomegranate juice over the last 10 years. This has resulted in pomegranate juice having a significantly higher cost than other juices, especially in comparison to apple, orange and grape juice.


This reference notebook offers a diverse mix of forensic applications that specifically highlight the unique performance characteristics of the AxION 2 TOF and AxION DSA. Learn how our techniques and technology can screen, confirm and quantify various known and unknown sample types across a wide range of forensic and research applications.

Testing and Quantification of Opioids in Serum by UHPLC-TOF

Testing of opioids is most commonly done using the Enzyme Multiple immunoassay Test (EMIT). Immunoassays suffer from non-specificity as they can only identify a class of drugs and cannot identify the specific compound within the class. As an example an immunoassay SAMHSA panel screens for opiates such as codeine and morphine but would not detect opioids such as oxycodone, which is a semi synthetic compound. This lack of specificity can lead to false positive or false negative results, needing confirmation by techniques such as GC/MS.

Testing and Quantification of Opioids in Urine by UHPLC-TOF

We present a study for screening of opioids along with the quantitation of the drugs in urine using a time-of-flight (TOF) mass spectrometer (MS) for use in forensic laboratories.

Whisky Origins Profiled By Data Fusion of LC/MS and ICP-MS Results Using TIBCO Spotfire Software

This study used TIBCO Spotfire® statistical analysis to investigate whether whisky compound profiles are specific to regional origins. Malt whiskies contain a large number of compounds, which vary according to the local ingredients, fermentation, distillation and maturation processes.

Workflow for Quantification of Benzodiazepines in Urine Using UHPLC- TOF

We present an alternative technique to quantitate benzodiazepines in urine utilizing a rapid dilute and shoot LC method in combination with time-of-flight mass spectrometry (TOF MS).



AxION 2 TOF Brochure

The AxION 2 TOF MS offers a broad array of capabilities designed to simplify and streamline virtually any analytical workflow. Whether your application places an emphasis on the instrument’s mass accuracy, full spectrum capability, speed, sensitivity,dynamic range, or all of the above, the AxION 2 TOF MS delivers exactly what you need to achieve confident, accurate results.

AxION Solo/Xpo Call Out Sheet

Designed for optimal flexibility and productivity, AxION® Solo™ streamlines the most complex LC/MS analyses by allowing you to define your own criteria and processing methods to find one or many substances by mass or formula. An intensity-driven heat mapping and graphical user interface provides superior visualization of results for quick interpretation and reporting. Whether you’re searching for single or multiple targets, AxION Solo allows you to take the fast, easy way to clear, confident analytical results.

PDF 295 KB


AxION eDoor SQ Flyer

From running an individual sample to managing a complete network of instruments and users, AxION® eDoor™ has the power to simplify every aspect of your laboratory operation. A robust yet intuitive open-access software, eDoor works with the Flexar™ SQ 300 MS to deliver reliable, high quality MS results no matter how complex your samples or workflows.

PDF 642 KB


Analysis of Impurities in Melatonin by LC/TOF-MS

Melatonin is a hormone secreted by the brain to help regulate sleep. Since melatonin is found in certain foods, it can be sold as a dietary “over-the-counter” (OTC) supplement.

PDF 270 KB
Confirmation of drugs of abuse in pseudo drug mixes using UHPLC-ESI TOF MS

Forensic crime labs are responsible for the qualitative confirmation of drugs of abuse for use in court cases. Gas chromatography mass spectrometry (GCMS) has been the gold standard for confirmation of cocaine, procaine, and morphine in confiscated illicit drugs.

PDF 224 KB

Technical Note


AxION 2 TOF MS Product Note

AxION 2 TOF TrapPulse TechNote

Designed for optimal flexibility and productivity, AxION® Solo™ streamlines the most complex LC/MS analyses by allowing you to define your own criteria and processing methods to find one or many substances by mass or formula. An intensity-driven heat mapping and graphical user interface provides superior visualization of results for quick interpretation and reporting. Whether you’re searching for single or multiple targets, AxION Solo allows you to take the fast, easy way to clear, confident analytical results.

PDF 228 KB