AxION 2 TOF MS

Liquid chromatography-mass spectrometry (LC/MS) is commonly used to measure drugs and their concentrations in extracts of biological matrices. Triple quadrupole MS is often employed for targeted quantitative analysis, using multiple reaction monitoring (MRM) mode. Here, the intensity of product ions ...

There is no standard method to quickly screen and confirm cathinones in bath salts. To address this issue, use of the AxION® Direct Sample Analysis™ (DSA™) integrated with the AxION 2 time-of-flight,mass spectrometer (TOF) (PerkinElmer, Waltham, MA) was implemented. Cathinone standards and bath salt ...

We present a study of PPCPs in river water samples from the northeastern United States using UHPLC-TOF-MS for both targeted and non-targeted analytes. Unlike a triple quadrupole, which is operated in multiple reaction monitoring mode for screening only predefined targeted analytes, the time-of-fligh ...

Quaternary ammonium compounds (QACs) have the basic structure NR4. Those possessing R groups with long alkyl chains are known to be especially effective as antimicrobial agents and particularly useful for the disinfection of containers and surfaces.

Screening methods for drugs of abuse,currently require long chromatographic,methods and sample preparation or,immunoassay techniques (EMIT) with,confirmation by GC/MS or LC/MS/MS.

The patterns of organic components in olive oils relate to the geographic origin, cultivar and processing methods for the olives. In this study a statistical analysis of the chemical components of authentic monovariatal virgin olive oils from Spain was used to determine markers for the cultivars. Th ...

Olives of different cultivars are used to produce oils with different particular flavors and stability. Oils of known cultivars from designated areas may be certified for authenticity, and are marketed internationally, commanding a price premium. This study reports on the measurement of the triacylg ...

Extra virgin olive oil has been adulterated throughout history with less expensive oils such as soybean or hazelnut oil. Detecting adulteration is important for maintaining both the safety and consumer confidence of this product. This study reports on the measurement of the triacylglyceride composit ...

Need to ensure quality, safety and reliability of food packaging? This compendium of Application Notes will provide you with R&D and QA/QC insights from plastic food trays, to bags, films and canned goods. The compendium provides research data and experimental results for; mechanical durability ...

Contamination of surfacewaters by algal blooms hasemerged as a public healthissue. Among the types ofalgae that can form algalblooms, photosynthetic cyanobacteria (also known as blue-green algae) can be particularlytoxic, and the level of toxicity can change very quickly. Issues with taste and od ...

LC/MS analysis showed that a number of non-endogenous compounds were detected in this urine.

Dietary supplement use is becoming more prevalent among adults. With this increased use there has been a concomitant rise in dietary supplement adulteration.

Polar components such as phenolic acids and lignans are present in olive oils. Secoiridoids; phenolics which include an elenolic acid moiety, are unique to the Olearaceae family. These compounds are known to have beneficial health effects due to their antioxidant properties and are associated with t ...

The EU Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) regulation was adopted in 2006 with the aim of protecting human and environmental health, along with the competitiveness of the chemical industry within the European Economic Area. The regulation places responsibi ...

This work highlights that screening, testing or real-time detection can be utilized to detect melamine-adulterated milk in a supply chain and that by determining where the sampling is taking place, who is carrying out the measurement and whether the testing is to meet regulation, will define which t ...

Presented is an alternative technique to quantitate benzodiazepines in plasma using a rapid protein precipitation method with a fast LC separation method in combination with TOF-MS.

The PerkinElmer AxION® Time of Flight (TOF), fitted with ADC detector technology, provides a wide dynamic range and is suitable for quantitative analysis of target along with qualitative screening of unknown compounds. In this application note we present a workflow for the testing and quantification ...

Adulteration of fruit juices is quite common in the market place and is often done through juice substitution. Pear juice has a slightly lower market value than apple juice yet both have similarities in major chemical composition, making pear juice an ideal adulterant for apple juice. Both juices ha ...

A variety of analytical techniques such as GC/MS, LC/MS, LC/UV, headspace GC/MS and stable isotope ratio analysis have been used to characterize vanilla bean extracts and detect its adulteration3-6. These measurement techniques are either expensive, time consuming, or both, and require extensive met ...

Olive oil and other oils are composed mainly of triacylglycerols. These molecules are derived from the esterification of three fatty acid molecules with a glycerol molecule. The main triglyceride in olive oil is triolein (OOO); whereas the main triglyceride in seed oils (soybean, corn and sunflower) ...

Pomegranate juice is in high demand due to its well documented health benefits. Studies based on a significant body of scientific research conducted on authentic pomegranate juice have,established that pomegranate juice has superior antioxidant activity compared to other popular fruit juices such as ...

This reference notebook offers a diverse mix of forensic applications that specifically highlight the unique performance characteristics of the AxION 2 TOF and AxION DSA. Learn how our techniques and technology can screen, confirm and quantify various known and unknown sample types across a wide ran ...

Testing of opioids is most commonly done using the Enzyme Multiple immunoassay Test (EMIT). Immunoassays suffer from non-specificity as they can only identify a class of drugs and cannot identify the specific compound within the class. As an example an immunoassay SAMHSA panel screens for opiates su ...

We present a study for screening of opioids along with the quantitation of the drugs in urine using a time-of-flight (TOF) mass spectrometer (MS) for use in forensic laboratories.

This study used TIBCO Spotfire® statistical analysis to investigate whether whisky compound profiles are specific to regional origins. Malt whiskies contain a large number of compounds, which vary according to the local ingredients, fermentation, distillation and maturation processes.

We present an alternative technique to quantitate benzodiazepines in urine utilizing a rapid dilute and shoot LC method in combination with time-of-flight mass spectrometry (TOF MS).

The AxION 2 TOF MS offers a broad array of capabilities designed to simplify and streamline virtually any analytical workflow. Whether your application places an emphasis on the instrument’s mass accuracy, full spectrum capability, speed, sensitivity,dynamic range, or all of the above, the AxION 2 T ...

Designed for optimal flexibility and productivity, AxION® Solo™ streamlines the most complex LC/MS analyses by allowing you to define your own criteria and processing methods to find one or many substances by mass or formula. An intensity-driven heat mapping and graphical user interface provides sup ...

From running an individual sample to managing a complete network of instruments and users, AxION® eDoor™ has the power to simplify every aspect of your laboratory operation. A robust yet intuitive open-access software, eDoor works with the Flexar™ SQ 300 MS to deliver reliable, high quality MS resul ...

Melatonin is a hormone secreted by the brain to help regulate sleep. Since melatonin is found in certain foods, it can be sold as a dietary “over-the-counter” (OTC) supplement.

Forensic crime labs are responsible for the qualitative confirmation of drugs of abuse for use in court cases. Gas chromatography mass spectrometry (GCMS) has been the gold standard for confirmation of cocaine, procaine, and morphine in confiscated illicit drugs.

AxION 2 TOF MS Product Note

Designed for optimal flexibility and productivity, AxION® Solo™ streamlines the most complex LC/MS analyses by allowing you to define your own criteria and processing methods to find one or many substances by mass or formula. An intensity-driven heat mapping and graphical user interface provides sup ...