PerkinElmer
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AlphaPlate-384, Light gray, untreated, Case of 50

384-well light gray microplates specifically designed for AlphaLISA and AlphaScreen assays.

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6005350
Case of 50
546.00 USD
 
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6005359
Case of 200
2077.00 USD
 
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Overview

Well Plate Dimensions

Well format: 384-well
Description Specification
Number of Rows 16
Number of Columns 24
Well volume 28 µL
Recommended working volume 10 µL- 20 µL
Height (mm) 14.35
Length (mm) 127.76
Width (mm) 85.48
Well diameter (mm) 3.3
Well depth (mm) 5.3
A1 to top offset (mm) 8.99
A1 to side offset (mm) 12.13
Well-to-well spacing (mm) 4.5

Specifications

Automation Compatible Yes
Coating Treatment Untreated
Color Gray
Detection Method Luminescence, Alpha
Material Polystyrene
Product Brand Name AlphaPlate
Shipping Condition Ambient
Sterile No
Unit Size Case of 50
Wells Number 384 well plate
Resources, Events & More
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Application Note

Effects of 5FU and Sorafenib on Proliferation and Biomarker Expression in a Colorectal Cancer Model Using AlphaLISA and EnSight Solutions

A variety of chemotherapeutic drugs with different modes of action have been developed and tested as potential therapies for colorectal cancer. Characterizing the effects of potential drugs with different modes of action is a key part of the process.

In this application note you will learn:

  • How to rapidly measure multiple biomarkers in both cell culture supernatant and lysates from the same wells of a microplate to examine complex protein expression profiles from a colorectal cancer cellular model
  • Benefits of using AlphaLISA® technology for characterizing the effects of potential drugs with different modes of action on a cell culture model of human colorectal cancer
  • How to measure the effects of drug treatments, such as 5FU and Sorafenib, on cellular proliferation by automated well-imaging and cell counting using the EnSight® multimode plate reader
  • Examples of the data and analysis you can generate for such biomarker and proliferation assays

PDF 3 MB
Rapid No Wash Assays for Characterizing a Mouse TIGIT/ PD-L1 Bispecific Antibody

Technical advancements in antibody engineering has brought about greater interest in more novel antibody therapeutic design and the emergence of new classes of antibody therapeutics called bispecific antibodies (bsAbs). The principle behind bispecific antibody design is to create an antibody / antibody fragment to two or more binding sites to help with the treatment of complex diseases.

As more bsAbs are produced as therapeutics, fast and accurate methods for functionally evaluating and characterizing the stability of these antibodies are necessary during both discovery and development stages, as well as during formulation and quality analysis.

In this application note, we demonstrate how AlphaLISA® assay technology with the EnVision® multimode plate reader can be used for bispecific antibody detection, through an example application to characterize the binding and specificity of a mouse bispecific antibody targeting mouse TIGIT and mouse PD-L1.

You will find out:

  • What bispecific antibodies are and how they differ from classical antibody formats
  • How to design quick and easy experiments to measure binding of the bispecific antibody to the target proteins
  • How a no-wash multiplex assay can show direct binding of each site to its respective target simultaneously in one well
  • How these assays could be used to evaluate the stability and functional reproducibility between batches of the bsAb preparations

PDF 1 MB