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AlphaLISA technology allows the detection of molecules of interest in buffer, cell culture media, serum and plasma in a highly sensitive, quantitative, reproducible and user-friendly mode. In an AlphaLISA assay, a Biotinylated Anti-Analyte Antibody binds to the Streptavidin-coated Alpha Donor beads, while another Anti-Analyte Antibody is conjugated to AlphaLISA Acceptor beads. In the presence of the analyte, the beads come into close proximity. The excitation of the Donor beads provokes the release of singlet oxygen molecules that triggers a cascade of energy transfer in the Acceptor beads, resulting in a sharp peak of light emission at 615 nm.
TNFR1 is a transmembrane receptor of TNF-α and TNF-β. The soluble form (sTNFR1) is released by the cell in inflammatory response. sTNFR1 interacts with free TNF-α to inhibit inflammation. Many neurological disorders are associated with high levels of serum TNFR1 such as, schizophrenia, bipolar, and dementia. Mutations of the gene which encodes TNFR1 may lead to tumor necrosis factor receptor associated periodic syndrome (TRAPS) and/or multiple sclerosis.
|Assay Target Class||Protein|
|Product Brand Name||AlphaLISA|
|Shipping Condition||Blue Ice|
|Unit Size||500 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Biomarkers provide insight into the presence and progression of disease states. Tumor necrosis factor 1 (TNF1) is a transmembrane protein that can be released by extracellular proteolytic cleavage to function as cytokines. Increased levels of soluble TNFR1 is an indicator for disease states such ...
Tumor Necrosis Factors (TNFs) are cytokines that are the primary modifiers of inflammatory and immune response. Researchers have shown that a soluble form of TNFR1 (sTNFR1) is a truncated version of the receptor produced by the disintegration and extracellular release of membranous protein on the ...