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Complement component 1q, also known as C1q, is a protein complex involved in the complement system. C1q senses antigen/antibody complexes formed with IgG or IgM and binds to antibody Fc via its globular heads. When this occurs, intramolecular rearrangement of the C1 complex is induced, triggering the activation of C1r and C1s proteases and the sequential cleavage of the circulating complement proteins. This leads to the formation of the Membrane Attack Complex (MAC) and to cell lysis. C1q binding measurements are related to the mechanism of action and Fc effector functions of biologics and therapeutic antibodies and utilized for studies in oncology, autoimmune disease, neurology, and infectious disease.
|Assay Points (200-50,000)||5000 Assay Points|
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Autoimmunity, Neuroscience, Infectious Disease (non-viral), Cardiovascular, Oncology, Inflammation, Metabolic, Rare Diseases, Respiratory, Immuno-oncology, Virology|
|Unit Size||5,000 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Alpha (Amplified Luminescent Proximity Homogeneous Assay) technology is a bead-based, no-wash alternative to traditional ELISAs. Instead of detection with an HRP substrate, the Alpha assay signal is generated by the excitation of an Eu+-coated bead that has been ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...
Biomarker levels were measured directly in CulturPlates-96 and-384 in a simple, fast, all-in-one-well AlphaLISA assay format. The elimination of transfer and wash steps simplifies cellular assays, reduces variability and significantly reduces hands-on time and costs associated with consumables. Int ...
The AlphaLISA® assay is a homogeneous immunoassay alternative to classical ELISA. AlphaLISA assays were originally utilized to detect analytesin cell cultures upernatants or serum/plasma samples.