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UNC-51 like autophagy activating kinase exists in two similar isoforms, ULK1 and ULK2. ULK1 is regulated by the key nutrient/energy-sensitive kinases mTOR and AMPK, which are both able to phosphorylate ULK1 and directly regulate its kinase activity. ULK1 forms a complex with the Atg13 and FIP200 proteins, this complex is the most upstream component of the core autophagy machinery and is, therefore, the key initiator of autophagy in mammalian cells. ULK1 is implicated in a variety of therapeutic areas including oncology, autoimmunity, neurology, and diabetes.
The AlphaLISA SureFire Human Phospho-ULK1 (Ser758) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-ULK1 (Ser758) in cellular lysates, using Alpha Technology.
|Assay Points (200-50,000)||50000 Assay Points|
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Autoimmunity, Neuroscience, Oncology, Metabolic, Immuno-oncology|
|Unit Size||50,000 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...