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Ubiquitin is a highly conserved regulatory protein found in most tissues of eukaryotic organism. Phosphorylation of ubiquitin is a key step in the process of mitochondria quality control through the Parkin/PINK-1 interaction. Parkin is a ubiquitin ligase E3 that conjugates ubiquitin to impaired-mitochondrial proteins, leading to organelle degradation. PINK1 is a Ser/Thr kinase that accumulates only on impaired mitochondria and phosphorylates two substrates, the ubiquitin-like domain of Parkin and ubiquitin chains. The amplified Parkin/PINK-1 dependent ubiquitin functions act as a signal for mitophagy. Dysregulation of this signaling is linked to neurodegenerative diseases such as Parkinson's Disease.
The AlphaLISA SureFire Ultra Human Phospho-Ubiquitin (Ser65) assay is a sandwich immunoassay for the quantitative detection of phospho-Ubiquitin (Ser65) in cellular lysates, using Alpha Technology.
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Central Nervous System|
|Unit Size||10,000 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...