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Serine/threonine-protein kinase acts downstream from ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81, and NR4A1/NUR77. It regulates translation through RPS6 and EIF4B phosphorylation and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing the pro-apoptotic function of BAD and DAPK1.
Upon extracellular signal or mitogen stimulation, RSK1 is phosphorylated at Thr-573 in the C-terminal kinase domain (CTD) by MAPK1/ERK2 and MAPK3/ERK1.
The AlphaLISA® SureFire® Ultra™ Phospho-RSK1 (Tyr573) assay is a sandwich immunoassay for quantitative detection of phospho-RSK1 in cellular lysates using Alpha Technology.
AlphaLISA SureFire Ultra kits are compatible with:
Alpha SureFire kits can be used for:
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Unit Size||50,000 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...