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Protein kinase R (PKR) is a kinase encoded by the EIF2AK2 gene and is involved in central cellular processes such as mRNA translation, transcriptional control, regulation of apoptosis, and proliferation. PKR plays a key role in the innate immunity pathway and is a mediator of the antiviral effects exerted by interferons. PKR also regulates eIF2α through phosphorylation. Dysregulation of PKR has been implicated in cancer, neurodegenerative disease, inflammation, and metabolic disorders.
The AlphaLISA SureFire Ultra Human Phospho-PKR (Thr451) assay is a sandwich immunoassay for the quantitative detection of phospho-PKR (Thr451) in cellular lysates, using Alpha Technology.
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Central Nervous System, Oncology, Metabolic|
|Unit Size||100 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...