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Protein kinase-like endoplasmic reticulum kinase (PERK) is an eIF2α kinase and transmembrane protein that resides in the endoplasmic reticulum (ER) membrane and is activated upon ER stress signals. PERK activation during ER stress correlates with autophosphorylation of its cytoplasmic kinase domain. Phosphorylation of PERK at Thr980 serves as a marker for its activation status. PERK promotes tumor growth by limiting oxidative DNA damage and is associated with neurodegenerative diseases and many cancers.
The AlphaLISA SureFire Human and Mouse Total PERK Detection Kit is a sandwich immunoassay for the quantitative detection of total PERK in cellular lysates, using Alpha Technology.
|Assay Points (200-50,000)||500 Assay Points|
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Target Species||Human, Mouse|
|Therapeutic Area||Neuroscience, Oncology|
|Unit Size||500 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...