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Mixed lineage kinase domain-like protein is encoded by the MLKL gene in murine species. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3) key signaling molecules in the necroptosis pathway. Inhibitor studies and knockdown of this gene inhibit TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children.
The AlphaLISA® SureFire® Ultra™ total mouse MLKL assay is a sandwich immunoassay for the quantitative detection of mouse MLKL (phosphorylated and non-phosphorylated) in cellular lysates, using Alpha Technology. This assay is intended to be used for normalization phosphorylation studies.
AlphaLISA SureFire Ultra kits are compatible with:
Alpha SureFire kits can be used for:
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Neuroinflammation, Oncology, Inflammation|
|Unit Size||500 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater assay throughput and sensitivity has evolved. In response, more robust immunoassays have been developed to address some of the limitations of the standard, colorimetric ELISA.
Find out about the most common limitations of traditional ELISAs and how different ELISA alternative technologies address these limitations.
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
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