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JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases which include JAK2, JAK3, and TYK2. Numerous cytokines and growth factors, such as IL-6, IL-4, IFN-α, GM-CSF, induce the phosphorylation of JAKs. Activated JAK subsequently phosphorylates additional targets, including both cytokine receptors and major substrates, STATs. The JAK/STAT signaling pathway stimulates cell proliferation, differentiation, migration, and apoptosis. Alterations to JAK/STAT signaling reduce cytokine induced pro-inflammatory responses, making it an attractive target for anti-inflammatory therapies.
The AlphaLISA SureFire Human Total JAK1 Detection Kit is a sandwich immunoassay for the quantitative detection of total JAK1 in cellular lysates, using Alpha Technology.
|Assay Points (200-50,000)||500 Assay Points|
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Autoimmunity, Oncology|
|Unit Size||500 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...