The AlphaLISA® SureFire® Ultra™ Total IRF3 assay is a sandwich immunoassay for quantitative detection of total IRF3 in cellular lysates using Alpha Technology.
This kit has been pre-validated for use in combination with Pelago Bioscience’s CETSA® (Cellular Thermal Shift Assay) technology. Please note that further assay optimization will be required in order to adapt the kit to your particular cell line and experimental conditions. A valid CETSA® licence from Pelago Bioscience or a single kit agreement is required for using the CETSA® technology.
For research use only; not for diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).
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Interferon regulatory factor 3 (IRF3) is a part of the IRF family which is involved in the regulation of interferon α and β and play a role in host anti-viral immune regulation, cell growth, and hematopoietic development. In viral infected cells, phosphorylation of transcription factor IRF3 induces the production of antiviral and proinflammatory cytokines, a key element in the type 1 interferon-independent innate immune response. IRF3 is activated downstream of the STING signaling pathway and toll-like receptor signaling pathway. IRF3 is associated with cancer and autoinflammatory disease.
The AlphaLISA SureFire Ultra Total IRF3 assay is a sandwich immunoassay for the quantitative detection of total IRF3 in cellular lysates, using Alpha Technology.
AlphaLISA SureFire Ultra kits are compatible with:
Alpha SureFire kits can be used for:
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Autoimmunity, Oncology|
|Unit Size||10,000 Assay Points|
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