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Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor α (IkBα) is a member of a family of cellular proteins that function to inhibit NF-kB transcription factor. When IkBα is phosphorylated by IKKβ, this prevents IkBα from inhibiting NF-kB which then frees NF-kB and allows it to enter the nucleus of the cell, where it activates various genes involved in inflammation and other immune responses. The IKKβ signaling pathway is associated with numerous therapeutic areas, including diseases such as multiple sclerosis, rheumatoid arthritis, psoriasis, and many types of cancers.
The AlphaLISA SureFire Ultra Human and Mouse Phospho-IkBα (Ser32/36) is a sandwich immunoassay for the quantitative detection of Phospho-IkBα (Ser32/36) in cellular lysates, using Alpha Technology.
|Assay Points (200-50,000)||500 Assay Points|
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Target Species||Human, Mouse|
|Therapeutic Area||Autoimmunity, Oncology, Immuno-oncology|
|Unit Size||500 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...