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Histone H3 is one of the five main histones involved in the structure of chromatin in eukaryotic cells. Histone H3 is the most extensively modified of the five histones and is phosphorylated during mitosis and meiosis. Aurora kinase B is directly responsible for mitotic Histone H3 Ser10 phosphorylation. Aurora kinase A is amplified in human cancers, with its overexpression in human tumors correlating with a poor prognosis and genomic instability. Histone H3 is implicated in glioblastomas, ovarian carcinomas, and hepatocellular carcinomas.
The AlphaLISA SureFire Ultra Human and Mouse Phospho-Histone H3 (Ser10/Thr11) assay is a sandwich immunoassay for the quantitative detection of phospho-histone H3 (Ser10/Thr11) in cellular lysates, using Alpha Technology.
|Assay Target||Histone H3|
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Target Species||Human, Mouse|
|Unit Size||100 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater assay throughput and sensitivity has evolved. In response, more robust immunoassays have been developed to address some of the limitations of the standard, colorimetric ELISA.
Find out about the most common limitations of traditional ELISAs and how different ELISA alternative technologies address these limitations.
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automated liquid handling, assays and reagents, imaging and detection systems, and informatics.
Working independently or together, with our solutions you can achieve consistent and accurate results. By accelerating the identification and characterization of effective and safe drug candidates, the PerkinElmer portfolio enables you to optimize efficiency in your lab and deliver more actionable, real-world results.
Download the brochure to learn more about how we can partner with you so that you can discover smarter, more effective, data-driven breakthroughs in the critical screening stages of drug discovery and development.